[HTML][HTML] Zika virus infects neural progenitors in the adult mouse brain and alters proliferation
Zika virus (ZIKV)-related neuropathology is an important global health concern. Several
studies have shown that ZIKV can infect neural stem cells in the developing brain, but …
studies have shown that ZIKV can infect neural stem cells in the developing brain, but …
[HTML][HTML] Zika virus disrupts phospho-TBK1 localization and mitosis in human neuroepithelial stem cells and radial glia
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other
neurodevelopment defects remain poorly understood. Here, we describe the derivation and …
neurodevelopment defects remain poorly understood. Here, we describe the derivation and …
Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate
KM Adams Waldorf, JE Stencel-Baerenwald… - Nature medicine, 2016 - nature.com
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a
pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved …
pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved …
[HTML][HTML] Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids
Zika virus (ZIKV) infection during pregnancy threatens pregnancy and fetal health. However,
the infectivity and pathological effects of ZIKV on placental trophoblast progenitor cells in …
the infectivity and pathological effects of ZIKV on placental trophoblast progenitor cells in …
Animal models of Zika virus infection, pathogenesis, and immunity
TE Morrison, MS Diamond - Journal of virology, 2017 - Am Soc Microbiol
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics
affecting millions of people on multiple continents. The virus has received global attention …
affecting millions of people on multiple continents. The virus has received global attention …
Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS 1‐caspase‐1 axis
Viral infection triggers host innate immune responses, which primarily include the activation
of type I interferon (IFN) signaling and inflammasomes. Here, we report that Zika virus (ZIKV) …
of type I interferon (IFN) signaling and inflammasomes. Here, we report that Zika virus (ZIKV) …
[HTML][HTML] Zika virus targets glioblastoma stem cells through a SOX2-integrin αvβ5 axis
Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other
brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem …
brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem …
Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys
P Abbink, RA Larocca, RA De La Barrera, CA Bricault… - Science, 2016 - science.org
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been
causally associated with fetal microcephaly. The development of a safe and effective ZIKV …
causally associated with fetal microcephaly. The development of a safe and effective ZIKV …
Type I interferons instigate fetal demise after Zika virus infection
Zika virus (ZIKV) infection during pregnancy is associated with adverse fetal outcomes,
including microcephaly, growth restriction, and fetal demise. Type I interferons (IFNs) are …
including microcephaly, growth restriction, and fetal demise. Type I interferons (IFNs) are …
[HTML][HTML] Mapping and role of the CD8+ T cell response during primary Zika virus infection in mice
AE Ngono, EA Vizcarra, WW Tang, N Sheets, Y Joo… - Cell host & …, 2017 - cell.com
CD8+ T cells may play a dual role in protection against and pathogenesis of flaviviruses,
including Zika virus (ZIKV). We evaluated the CD8+ T cell response in ZIKV-infected …
including Zika virus (ZIKV). We evaluated the CD8+ T cell response in ZIKV-infected …