The evolution of Zika virus from Asia to the Americas

ZY Liu, WF Shi, CF Qin - Nature Reviews Microbiology, 2019 - nature.com
Zika virus (ZIKV) was once considered an obscure member of the large and diverse family of
mosquito-borne flaviviruses, and human infections with ZIKV were thought to be sporadic …

Vulnerability of primitive human placental trophoblast to Zika virus

MA Sheridan, D Yunusov… - Proceedings of the …, 2017 - National Acad Sciences
Infection of pregnant women by Asian lineage strains of Zika virus (ZIKV) has been linked to
brain abnormalities in their infants, yet it is uncertain when during pregnancy the human …

An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model

JS Chahal, T Fang, AW Woodham, OF Khan, J Ling… - Scientific reports, 2017 - nature.com
The Zika virus (ZIKV) outbreak in the Americas and South Pacific poses a significant burden
on human health because of ZIKV's neurotropic effects in the course of fetal development …

Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy

SS Foo, W Chen, Y Chan, JW Bowman, LC Chang… - Nature …, 2017 - nature.com
Blood CD14+ monocytes are frontline immunomodulators categorized into classical,
intermediate or non-classical subsets, and subsequently differentiated into M1 pro-or M2 …

Broadly neutralizing activity of Zika virus-immune sera identifies a single viral serotype

KA Dowd, CR DeMaso, RS Pelc, SD Speer, ARY Smith… - Cell reports, 2016 - cell.com
Recent epidemics of Zika virus (ZIKV) have been associated with congenital malformation
during pregnancy and Guillain-Barré syndrome. There are two ZIKV lineages (African and …

AXL-mediated productive infection of human endothelial cells by Zika virus

S Liu, LJ DeLalio, BE Isakson, TT Wang - Circulation research, 2016 - Am Heart Assoc
Rationale: The mosquito-borne Zika virus (ZIKV) is now recognized as a blood-borne
pathogen, raising an important question about how the virus gets into human bloodstream …

Zika (PRVABC59) infection is associated with T cell infiltration and neurodegeneration in CNS of immunocompetent neonatal C57Bl/6 mice

M Manangeeswaran, DDC Ireland, D Verthelyi - PLoS pathogens, 2016 - journals.plos.org
The recent spread of Zika virus (ZIKV) and its association with increased rates of Guillain
Barre and other neurological disorders as well as congenital defects that include …

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

C Shan, AE Muruato, BW Jagger, J Richner… - Nature …, 2017 - nature.com
Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The
persistence of Zika virus in the male reproductive system poses a risk of sexual …

Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs

JFW Chan, CCY Yip, JOL Tsang, KM Tee… - Emerging microbes & …, 2016 - Taylor & Francis
Zika virus (ZIKV) is unique among human-pathogenic flaviviruses by its association with
congenital anomalies and trans-placental and sexual human-to-human transmission …

Zika virus-associated neurological disorders: a review

AQC Araujo, MTT Silva, APQC Araujo - Brain, 2016 - academic.oup.com
Zika virus, an arbovirus transmitted by mosquitoes of the Aedes species, is now rapidly
disseminating throughout the Americas and the ongoing Brazilian outbreak is the largest …