Cells generate and sustain mechanical forces within their environment as part of their
normal physiology. They are active materials that can detect mechanical stimulation by the …

The tumour microenvironment plays a critical role in determining tumour fate. Within that
environment, and indeed throughout epithelial tissues, cells experience competition with …

A main goal of mathematical and computational oncology is to develop quantitative tools to
determine the most effective therapies for each individual patient. This involves predicting …

Cell activity is coordinated by dynamic interactions with the extracellular matrix, often
through stimuli‐mediated spatiotemporal stiffening and softening. Dynamic changes in …

Many factors including growth factors (GF), scaffold materials, and chemical and physical
cues determine the cell behaviors. For many years, growth factors have been considered as …

From a biophysical standpoint, the interface between the cell membrane and the
cytoskeleton is an intriguing site where a “two-dimensional fluid” interacts with an …

One of the hallmarks of the malignant transformation of epithelial tissue is the modulation of
stromal components of the microenvironment. In particular, aberrant extracellular matrix …

While the mechanotransduction-induced fate of adult neural stem/progenitor cells (NPCs) is
relatively known, how substrate stiffness regulates the temporal evolution of the …

Vinculin can interact with F-actin both in recruitment of actin filaments to the growing focal
adhesions and also in capping of actin filaments to regulate actin dynamics. Using …

Micro-environmental regulation of cancer cell malignancy is one of the most basic cancer life
phenomena. However, the study of cellular response to microenvironment has been long …