Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …

Activating mutations in the epidermal growth factor receptor gene occur as early cancer-
driving clonal events in a subset of patients with non-small cell lung cancer (NSCLC) and …

Despite the development of second-generation antiandrogens, acquired resistance to
hormone therapy remains a major challenge in treating advanced prostate cancer. We find …

Dysregulated mitochondrial function is a hallmark of immune-mediated inflammatory
diseases. Cytochrome c oxidase (C c O), which mediates the rate-limiting step in …

Tumor heterogeneity underlies resistance to tyrosine kinase inhibitors (TKI) in lung cancers
harboring EGFR mutations. Previous evidence suggested that subsets of preexisting …

Resistance is the major cause of treatment failure and disease progression in non-small cell
lung cancer (NSCLC). There is evidence that hypoxia is a key microenvironmental stress …

The mitochondrial electron transport chain (mtETC) requires mainly coenzyme Q10
(CoQ10), copper (Cu 2+), calcium (Ca 2+), and iron (Fe 2+) ions for efficient ATP production …

Abstract Dual-specificity phosphatase 8 (DUSP8) plays an important role as a selective c-
Jun N-terminal kinase (JNK) phosphatase in mitogen-activated protein kinase (MAPK) …

Introduction The treatment of patients with EGFR-mutant NSCLC with vascular endothelial
growth factor (VEGF) inhibitors in combination with EGFR inhibitors provides a greater …

Motivation With the rapid advances of RNA sequencing and microarray technologies in non-
coding RNA (ncRNA) research, functional tools that perform enrichment analysis for ncRNAs …