In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase
It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …
Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats
Cocaine dependence is a serious world-wide public health problem without an FDA-
approved pharmacotherapy. We recently designed and discovered a highly efficient long …
approved pharmacotherapy. We recently designed and discovered a highly efficient long …
Preclinical and clinical developments in enzyme-loaded red blood cells: an update
Introduction We have previously described the preclinical developments in enzyme-loaded
red blood cells to be used in the treatment of several rare diseases, as well as in chronic …
red blood cells to be used in the treatment of several rare diseases, as well as in chronic …
Kinetic characterization of an efficient cocaine hydrolase against toxic metabolites of cocaine
In the presence of alcohol, cocaine metabolism produces a number of metabolites, including
three toxic ones (cocaethylene, norcocaine, and norcocaethylene) which are all more toxic …
three toxic ones (cocaethylene, norcocaine, and norcocaethylene) which are all more toxic …
Identification of key genes and therapeutic drugs for cocaine addiction using integrated bioinformatics analysis
X Wang, S Sun, H Chen, B Yun, Z Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction Cocaine is a highly addictive drug that is abused due to its excitatory effect on
the central nervous system. It is critical to reveal the mechanisms of cocaine addiction and …
the central nervous system. It is critical to reveal the mechanisms of cocaine addiction and …
Cocaine-derived hippuric acid activates mtDNA-STING signaling in alcoholic liver disease: Implications for alcohol and cocaine co-abuse
GR Lee, H Ma, JS Park, J Lee, F Wang, Y Ma, GY Sui… - 2024 - papers.ssrn.com
The simultaneous abuse of alcohol-cocaine is known to cause stronger and more
unpredictable cellular damage in the liver, heart, and brain. However, the crosstalk between …
unpredictable cellular damage in the liver, heart, and brain. However, the crosstalk between …
Síntesis de un organocatalizador biomimético para reacciones de transesterificación.
A Sánchez Alonso - 2024 - gredos.usal.es
[ES] En este TFG se propone la síntesis de un organocatalizador que mimetice el centro
activo de enzimas hidrolasas. Las enzimas tienen una gran aplicación en la industria pero …
activo de enzimas hidrolasas. Las enzimas tienen una gran aplicación en la industria pero …