MALDI imaging of lipid biochemistry in tissues by mass spectrometry

KA Zemski Berry, JA Hankin, RM Barkley… - Chemical …, 2011 - ACS Publications
As a result of recent advances, remarkable images revealing the distribution of complex
lipids in tissues are now generated by matrix-assisted laser desorption/ionization imaging …

Sialidases in vertebrates: a family of enzymes tailored for several cell functions

E Monti, E Bonten, A D'Azzo, R Bresciani… - Advances in …, 2010 - Elsevier
A bstract This review summarizes the recent research development on vertebrate sialidase
biology. Sialic acid-containing compounds play important roles in many physiological …

A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein …

L Boccuto, K Aoki, H Flanagan-Steet… - Human molecular …, 2014 - academic.oup.com
Abstract 'Salt & Pepper'syndrome is an autosomal recessive condition characterized by
severe intellectual disability, epilepsy, scoliosis, choreoathetosis, dysmorphic facial features …

Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc as a neuroprotective drug target

P Albrecht, J Lewerenz, S Dittmer… - CNS & Neurological …, 2010 - ingentaconnect.com
The glutamate/cystine antiporter system xc¯ transports cystine into cells in exchange for the
important neurotransmitter glutamate at a ratio of 1: 1. It is composed of a specific light chain …

Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases

J Fantini, N Yahi - Expert Reviews in Molecular Medicine, 2010 - cambridge.org
Alzheimer, Parkinson and other neurodegenerative diseases involve a series of brain
proteins, referred to as 'amyloidogenic proteins', with exceptional conformational plasticity …

Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina

M Kurzawa‐Akanbi, P Whitfield, F Burté… - Journal of …, 2022 - Wiley Online Library
Age‐related macular degeneration (AMD) is a leading cause of blindness. Vision loss is
caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal …

[PDF][PDF] Mechanisms of cancer-associated glycosylation changes

F Dall'Olio, N Malagolini, M Trinchera… - Front Biosci, 2012 - article.imrpress.com
Introduction 3. Survey of cancer-associated glycosylation changes 3.1. β1, 6 branching 3.2.
Sialyl Lewis antigens 3.3. α2, 6-sialylated lactosamine (Sia6LacNAc) 3.4. T, Tn and sialyl-Tn …

Sialosignaling: Sialyltransferases as engines of self-fueling loops in cancer progression

F Dall'Olio, N Malagolini, M Trinchera… - Biochimica et Biophysica …, 2014 - Elsevier
Background Glycosylation is increasingly recognized as one of the most relevant
postranslational modifications. Sialic acids are negatively charged sugars which frequently …

[HTML][HTML] Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity

C Kubota, S Torii, N Hou, N Saito, Y Yoshimoto… - Journal of Biological …, 2010 - ASBMB
Reactive oxygen species (ROS) are involved in several cell death processes, including
cerebral ischemic injury. We found that glutamate-induced ROS accumulation and the …

Aligned carbon nanotube reinforced polymeric scaffolds with electrical cues for neural tissue regeneration

P Gupta, S Sharan, P Roy, D Lahiri - Carbon, 2015 - Elsevier
In this article, the challenge of providing electrical cue through a soft polymeric neural
scaffold for directional neuron growth has been studied. Aligned multiwalled carbon …