SARS-CoV-2 infection in children and implications for vaccination

J Nathanielsz, ZQ Toh, LAH Do, K Mulholland… - Pediatric …, 2023 - nature.com
The COVID-19 pandemic caused by novel severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) is responsible for more than 500 million cases worldwide as of April 2022 …

Understanding COVID-19 in children: immune determinants and post-infection conditions

GA Rotulo, P Palma - Pediatric research, 2023 - nature.com
Coronavirus disease 2019 in children presents with milder clinical manifestations than in
adults. On the other hand, the presence of a wide range of inflammatory manifestations …

Circulating spike protein detected in post–COVID-19 mRNA vaccine myocarditis

LM Yonker, Z Swank, YC Bartsch, MD Burns, A Kane… - Circulation, 2023 - Am Heart Assoc
Background: Cases of adolescents and young adults developing myocarditis after
vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted …

[HTML][HTML] Effectiveness of BNT162b2 (Pfizer-BioNTech) mRNA vaccination against multisystem inflammatory syndrome in children among persons aged 12–18 years …

LD Zambrano - MMWR. Morbidity and mortality weekly report, 2022 - cdc.gov
The Pfizer-BioNTech vaccine, currently authorized for persons aged≥ 5 years, provides a
high level of protection against severe COVID-19 in persons aged 12–18 years. Vaccine …

Reported cases of multisystem inflammatory syndrome in children aged 12–20 years in the USA who received a COVID-19 vaccine, December, 2020, through August …

AR Yousaf, MM Cortese, AW Taylor… - The Lancet Child & …, 2022 - thelancet.com
Background Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory
condition associated with antecedent SARS-CoV-2 infection. In the USA, reporting of MIS-C …

Risk and phenotype of multisystem inflammatory syndrome in vaccinated and unvaccinated Danish children before and during the omicron wave

M Holm, L Espenhain, J Glenthøj, LS Schmidt… - JAMA …, 2022 - jamanetwork.com
Methods| This population-based cohort study prospectively included patients aged 0 to 17
years with MIS-C from all 18 Danish pediatric departments. Patients were diagnosed from …

Risk factors for multisystem inflammatory syndrome in children–A population-based cohort study of over 2 million children

S Rhedin, C Lundholm, AC Horne, AI Smew… - The Lancet Regional …, 2022 - thelancet.com
Background Although severe acute COVID-19 is rare in children, SARS-CoV-2 infection can
trigger the novel post-infectious condition multisystem inflammatory syndrome in children …

Hyper inflammatory syndrome following COVID-19 mRNA vaccine in children: a national post-authorization pharmacovigilance study

N Ouldali, H Bagheri, F Salvo, D Antona… - The Lancet Regional …, 2022 - thelancet.com
Background Multisystem inflammatory syndrome in children (MIS-C) is the most severe
clinical entity associated with pediatric SARS-CoV-2 infection with a putative role of the …

Effectiveness of BBIBP-CorV, BNT162b2 and mRNA-1273 vaccines against hospitalisations among children and adolescents during the Omicron outbreak in …

S González, S Olszevicki, A Gaiano… - The Lancet Regional …, 2022 - thelancet.com
Background Although paediatric clinical presentations of COVID-19 are usually less severe
than in adults, serious illness and death have occurred. Many countries started the …

COVID-19 and inborn errors of immunity

OM Delmonte, R Castagnoli, LD Notarangelo - Physiology, 2022 - journals.physiology.org
Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune
host defense and immunoregulation. Considering the predisposition to develop severe and …