Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

The immune system plays a significant role in multiple sclerosis. While MS was historically
thought to be T cell-mediated, multiple pieces of evidence now support the view that B cells …

In this 14th installment of the annual Antibodies to Watch article series, we discuss key
events in commercial monoclonal antibody therapeutics development that occurred in 2022 …

Abstract Purpose of Review In this review, we provide a comprehensive update on current
scientific advances and emerging therapeutic approaches in the field of multiple sclerosis …

Myasthenia gravis (MG) is an autoimmune disorder that affects the neuromuscular junction,
leading to muscle weakness and fatigue. MG is caused by antibodies against the …

This review addresses current changes in the approach to treating patients with multiple
sclerosis (MS). The widely practiced approach of utilizing agents with lower treatment …

In recent decades there has been a large focus on understanding the mechanisms of
peripheral immune cell infiltration into the central nervous system (CNS) in …

Background B cells can be enriched within meningeal immune-cell aggregates of multiple
sclerosis (MS) patients, adjacent to subpial cortical demyelinating lesions now recognized …

Ublituximab (ublituximab-xiiy; BRIUMVI™) is a glycoengineered anti-CD20 monoclonal
antibody developed by TG Therapeutics, Inc. for the treatment of multiple sclerosis (MS). The …

Cumulative evidence along several lines indicates that B cells play an important role in the
pathological course of multiple sclerosis (MS), neuromyelitisoptica spectrum disorders …