The use of alternative strategies for enhanced nanoparticle delivery to solid tumors

M Izci, C Maksoudian, BB Manshian… - Chemical …, 2021 - ACS Publications
Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

Where is nano today and where is it headed? A review of nanomedicine and the dilemma of nanotoxicology

C Domingues, A Santos, C Alvarez-Lorenzo… - ACS …, 2022 - ACS Publications
Worldwide nanotechnology development and application have fueled many scientific
advances, but technophilic expectations and technophobic demands must be …

Lipid nanoparticles for nucleic acid delivery: Current perspectives

E Samaridou, J Heyes, P Lutwyche - Advanced drug delivery reviews, 2020 - Elsevier
Nucleic Acid (NA) based therapeutics are poised to disrupt modern medicine and augment
traditional pharmaceutics in a meaningful way. However, a key challenge to advancing NA …

[HTML][HTML] Knife's edge: Balancing immunogenicity and reactogenicity in mRNA vaccines

J Lee, MC Woodruff, EH Kim, JH Nam - Experimental & Molecular …, 2023 - nature.com
Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to
wield them in the development of therapeutics and vaccines. During the COVID-19 …

[HTML][HTML] Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety

I Vlatkovic - Biomedicines, 2021 - mdpi.com
Lipid nanoparticle (LNP) formulated messenger RNA-based (LNP-mRNA) vaccines came
into the spotlight as the first vaccines against SARS-CoV-2 virus to be applied worldwide …

In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design

PM Cevaal, A Ali, E Czuba-Wojnilowicz, J Symons… - ACS …, 2021 - ACS Publications
T cells play an important role in immunity and repair and are implicated in diseases,
including blood cancers, viral infections, and inflammation, making them attractive targets for …

[HTML][HTML] Recent advances in lipid nanoparticles for delivery of mRNA

L Yang, L Gong, P Wang, X Zhao, F Zhao, Z Zhang… - Pharmaceutics, 2022 - mdpi.com
Messenger RNA (mRNA), which is composed of ribonucleotides that carry genetic
information and direct protein synthesis, is transcribed from a strand of DNA as a template …

Albumin-hitchhiking: fostering the pharmacokinetics and anticancer therapeutics

P Famta, S Shah, N Jain, DA Srinivasarao… - Journal of Controlled …, 2023 - Elsevier
Nanotherapeutics demonstrate poor accumulation in the tumor microenvironment due to
poor extravasation and penetration into the tumor. Therapeutics such as oligonucleotides …

Rational design of polymeric micelles for targeted therapeutic delivery

Y Zheng, Y Oz, Y Gu, N Ahamad, K Shariati… - Nano Today, 2024 - Elsevier
Polymeric micellar drug carriers have emerged as effective tools to enhance the solubility
and bioavailability of hydrophobic drugs. These micelles possess a nano size structure that …

[HTML][HTML] Challenges towards targeted drug delivery in cancer nanomedicines

MN Hafeez, C Celia, V Petrikaite - Processes, 2021 - mdpi.com
Despite cancer nanomedicine celebrates already thirty years since its introduction, together
with the achievements and progress in cancer treatment area, it still undergoes serious …