The use of alternative strategies for enhanced nanoparticle delivery to solid tumors
M Izci, C Maksoudian, BB Manshian… - Chemical …, 2021 - ACS Publications
Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …
decade. Classically, scientists have tried to improve NM delivery by employing passive or …
Where is nano today and where is it headed? A review of nanomedicine and the dilemma of nanotoxicology
C Domingues, A Santos, C Alvarez-Lorenzo… - ACS …, 2022 - ACS Publications
Worldwide nanotechnology development and application have fueled many scientific
advances, but technophilic expectations and technophobic demands must be …
advances, but technophilic expectations and technophobic demands must be …
Lipid nanoparticles for nucleic acid delivery: Current perspectives
E Samaridou, J Heyes, P Lutwyche - Advanced drug delivery reviews, 2020 - Elsevier
Nucleic Acid (NA) based therapeutics are poised to disrupt modern medicine and augment
traditional pharmaceutics in a meaningful way. However, a key challenge to advancing NA …
traditional pharmaceutics in a meaningful way. However, a key challenge to advancing NA …
[HTML][HTML] Knife's edge: Balancing immunogenicity and reactogenicity in mRNA vaccines
Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to
wield them in the development of therapeutics and vaccines. During the COVID-19 …
wield them in the development of therapeutics and vaccines. During the COVID-19 …
[HTML][HTML] Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety
I Vlatkovic - Biomedicines, 2021 - mdpi.com
Lipid nanoparticle (LNP) formulated messenger RNA-based (LNP-mRNA) vaccines came
into the spotlight as the first vaccines against SARS-CoV-2 virus to be applied worldwide …
into the spotlight as the first vaccines against SARS-CoV-2 virus to be applied worldwide …
In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design
T cells play an important role in immunity and repair and are implicated in diseases,
including blood cancers, viral infections, and inflammation, making them attractive targets for …
including blood cancers, viral infections, and inflammation, making them attractive targets for …
[HTML][HTML] Recent advances in lipid nanoparticles for delivery of mRNA
L Yang, L Gong, P Wang, X Zhao, F Zhao, Z Zhang… - Pharmaceutics, 2022 - mdpi.com
Messenger RNA (mRNA), which is composed of ribonucleotides that carry genetic
information and direct protein synthesis, is transcribed from a strand of DNA as a template …
information and direct protein synthesis, is transcribed from a strand of DNA as a template …
Albumin-hitchhiking: fostering the pharmacokinetics and anticancer therapeutics
Nanotherapeutics demonstrate poor accumulation in the tumor microenvironment due to
poor extravasation and penetration into the tumor. Therapeutics such as oligonucleotides …
poor extravasation and penetration into the tumor. Therapeutics such as oligonucleotides …
Rational design of polymeric micelles for targeted therapeutic delivery
Polymeric micellar drug carriers have emerged as effective tools to enhance the solubility
and bioavailability of hydrophobic drugs. These micelles possess a nano size structure that …
and bioavailability of hydrophobic drugs. These micelles possess a nano size structure that …
[HTML][HTML] Challenges towards targeted drug delivery in cancer nanomedicines
MN Hafeez, C Celia, V Petrikaite - Processes, 2021 - mdpi.com
Despite cancer nanomedicine celebrates already thirty years since its introduction, together
with the achievements and progress in cancer treatment area, it still undergoes serious …
with the achievements and progress in cancer treatment area, it still undergoes serious …