Signaling and transcriptional networks in heart development and regeneration
BG Bruneau - Cold Spring Harbor perspectives in …, 2013 - cshperspectives.cshlp.org
The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …
formation and function are essential for fetal life. Defects in heart formation lead to …
TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed
AD Mori, BG Bruneau - Current opinion in cardiology, 2004 - journals.lww.com
Genetic analysis of patient populations and the biochemical characterization of the mutated
proteins have provided considerable insight into the function of TBX5 in cardiac …
proteins have provided considerable insight into the function of TBX5 in cardiac …
Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation
Sex disparities in cardiac homeostasis and heart disease are well documented, with
differences attributed to actions of sex hormones. However, studies have indicated sex …
differences attributed to actions of sex hormones. However, studies have indicated sex …
Hypoplastic left heart syndrome is heritable
RB Hinton, LJ Martin, ME Tabangin, ML Mazwi… - Journal of the American …, 2007 - jacc.org
Objectives: This study sought to determine the size of the genetic effect (heritability) in
families identified by a hypoplastic left heart syndrome (HLHS) proband. Background …
families identified by a hypoplastic left heart syndrome (HLHS) proband. Background …
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development
JK Takeuchi, M Mileikovskaia, K Koshiba-Takeuchi… - 2005 - journals.biologists.com
To elucidate the function of the T-box transcription factor Tbx20 in mammalian development,
we generated a graded loss-of-function series by transgenic RNA interference in entirely …
we generated a graded loss-of-function series by transgenic RNA interference in entirely …
[HTML][HTML] Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation
L Xie, AD Hoffmann, O Burnicka-Turek… - Developmental cell, 2012 - cell.com
The developmental mechanisms underlying human congenital heart disease (CHD) are
poorly understood. Atrial septal defects (ASDs) can result from haploinsufficiency of …
poorly understood. Atrial septal defects (ASDs) can result from haploinsufficiency of …
Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation
GATA4, an essential cardiogenic transcription factor, provides a model for dominant
transcription factor mutations in human disease. Dominant GATA4 mutations cause …
transcription factor mutations in human disease. Dominant GATA4 mutations cause …
Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium
NJ VanDusen, J Casanovas, JW Vincentz, BA Firulli… - Cell reports, 2014 - cell.com
The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during
cardiac morphogenesis via expression and function within myocardial, neural crest, and …
cardiac morphogenesis via expression and function within myocardial, neural crest, and …
Cyp26 enzymes facilitate second heart field progenitor addition and maintenance of ventricular integrity
AB Rydeen, JS Waxman - PLoS biology, 2016 - journals.plos.org
Although retinoic acid (RA) teratogenicity has been investigated for decades, the
mechanisms underlying RA-induced outflow tract (OFT) malformations are not understood …
mechanisms underlying RA-induced outflow tract (OFT) malformations are not understood …
Genetics of hypoplastic left heart syndrome
D. Woodrow Benson, MD, PhD1, Lisa J. Martin, PhD2, and Cecilia W. Lo, PhD3 Hypoplastic
left heart syndrome (HLHS; MIM# 241550) is a severe congenital heart defect (CHD) …
left heart syndrome (HLHS; MIM# 241550) is a severe congenital heart defect (CHD) …