Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …

In the 10 years since our previous International Union of Basic and Clinical Pharmacology
report on the nomenclature and classification of adenosine receptors, no developments …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …

The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains
unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent …

Adenosine is an autacoid that plays a critical role in regulating cardiac function, including
heart rate, contractility, and coronary flow. In this chapter, current knowledge of the functions …

Adenosine receptor ligands have anti-inflammatory effects and modulate immune responses
by up-regulating IL-10 production by immunostimulated macrophages. The adenosine …

The purine nucleoside adenosine is consensually identified as a major local regulator of
tissue function especially when energy supply fails to meet cellular energy demand. Due to …

Adenosine is a nucleoside that impacts the cardiovascular system via the activation of its
membrane receptors, named A1R, A2AR, A2BR and A3R. Adenosine is released during …

Background Acute renal failure from ischemia significantly contributes to morbidity and
mortality in clinical settings, and strategies to improve renal resistance to ischemia are …

Adenosine is an ubiquitous extracellular signaling molecule and plays a fundamental role in
the regulation of coronary microcirculation through activation of adenosine receptors (ARs) …