Adenosine receptors as drug targets—what are the challenges?
JF Chen, HK Eltzschig, BB Fredholm - Nature reviews Drug discovery, 2013 - nature.com
Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors—an update
BB Fredholm, AP IJzerman, KA Jacobson… - Pharmacological …, 2011 - ASPET
In the 10 years since our previous International Union of Basic and Clinical Pharmacology
report on the nomenclature and classification of adenosine receptors, no developments …
report on the nomenclature and classification of adenosine receptors, no developments …
Cardiovascular adenosine receptors: expression, actions and interactions
JP Headrick, KJ Ashton, RB Rose'Meyer… - Pharmacology & …, 2013 - Elsevier
Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …
Hyperhomocysteinemia and cardiovascular disease: is the adenosinergic system the missing link?
F Paganelli, G Mottola, J Fromonot, M Marlinge… - International journal of …, 2021 - mdpi.com
The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains
unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent …
unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent …
[图书][B] Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology
SJ Mustafa, RR Morrison, B Teng, A Pelleg - 2009 - Springer
Adenosine is an autacoid that plays a critical role in regulating cardiac function, including
heart rate, contractility, and coronary flow. In this chapter, current knowledge of the functions …
heart rate, contractility, and coronary flow. In this chapter, current knowledge of the functions …
Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism
Adenosine receptor ligands have anti-inflammatory effects and modulate immune responses
by up-regulating IL-10 production by immunostimulated macrophages. The adenosine …
by up-regulating IL-10 production by immunostimulated macrophages. The adenosine …
Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility
The purine nucleoside adenosine is consensually identified as a major local regulator of
tissue function especially when energy supply fails to meet cellular energy demand. Due to …
tissue function especially when energy supply fails to meet cellular energy demand. Due to …
Adenosine and the cardiovascular system: the good and the bad
R Guieu, JC Deharo, B Maille, L Crotti… - Journal of clinical …, 2020 - mdpi.com
Adenosine is a nucleoside that impacts the cardiovascular system via the activation of its
membrane receptors, named A1R, A2AR, A2BR and A3R. Adenosine is released during …
membrane receptors, named A1R, A2AR, A2BR and A3R. Adenosine is released during …
The reno-vascular A2B adenosine receptor protects the kidney from ischemia
A Grenz, H Osswald, T Eckle, D Yang, H Zhang… - PLoS …, 2008 - journals.plos.org
Background Acute renal failure from ischemia significantly contributes to morbidity and
mortality in clinical settings, and strategies to improve renal resistance to ischemia are …
mortality in clinical settings, and strategies to improve renal resistance to ischemia are …
Adenosine and adenosine receptor-mediated action in coronary microcirculation
Y Zhang, B Wernly, X Cao, SJ Mustafa, Y Tang… - Basic Research in …, 2021 - Springer
Adenosine is an ubiquitous extracellular signaling molecule and plays a fundamental role in
the regulation of coronary microcirculation through activation of adenosine receptors (ARs) …
the regulation of coronary microcirculation through activation of adenosine receptors (ARs) …