The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …

Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer's disease, leads to
blood–brain barrier (BBB) breakdown in humans and mice. Remarkably, BBB dysfunction …

The blood-brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …

Diabetes mellitus is one of the major risk factors for cognitive dysfunction. The pathogenesis
of brain impairment caused by chronic hyperglycemia is complex and includes …

Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …

Obesity promotes diverse pathologies, including atherosclerosis and dementia, which
frequently involve vascular defects and endothelial cell (EC) dysfunction. Each organ has …

Hypertension is a leading cause of stroke and dementia, effects attributed to disrupting
delivery of blood flow to the brain. Hypertension also alters the blood-brain barrier (BBB), a …

Vascular dysfunction is frequently observed in disorders associated with cognitive
impairment, dementia and Alzheimer's disease (AD). Recent advances in neuroimaging and …

Accumulating clinical observations suggest pathogenesis beyond viral pneumonia and its
secondary consequences in COVID-19 patients. In particular, many patients develop …

In 2018, there was a recent shift towards a biological definition of Alzheimer's disease (AD),
based on biomarkers measured in vivo even before the onset of clinical dementia …