[HTML][HTML] 3D printing technologies in personalized medicine, nanomedicines, and biopharmaceuticals

DR Serrano, A Kara, I Yuste, FC Luciano, B Ongoren… - Pharmaceutics, 2023 - mdpi.com
3D printing technologies enable medicine customization adapted to patients' needs. There
are several 3D printing techniques available, but majority of dosage forms and medical …

[HTML][HTML] The functional and clinical roles of liquid biopsy in patient-derived models

Z Zhu, E Hu, H Shen, J Tan, S Zeng - Journal of Hematology & Oncology, 2023 - Springer
The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters
in blood, as well as the detection of, cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) …

Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids

FA Yousef Yengej, J Jansen… - Proceedings of the …, 2023 - National Acad Sciences
Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven
valuable for studies of kidney development, disease, and therapeutic screening. However …

Global Meta-Analysis of Organoid and Organ-on-Chip Research.

J Shoji, RP Davis, CL Mummery… - Advanced healthcare …, 2023 - duo.uio.no
Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical,
physiological, or pathological states of tissues and organs. These technologies are widely …

[HTML][HTML] Application of microfluidic chips in the simulation of the urinary system microenvironment

C Hou, Y Gu, W Yuan, W Zhang, X Xiu, J Lin, Y Gao… - Materials Today Bio, 2023 - Elsevier
The urinary system, comprising the kidneys, ureters, bladder, and urethra, has a unique
mechanical and fluid microenvironment, which is essential to the urinary system growth and …

[HTML][HTML] Innovating spinal muscular atrophy models in the therapeutic era

I Signoria, WL van der Pol… - Disease Models & …, 2023 - journals.biologists.com
Spinal muscular atrophy (SMA) is a severe, monogenetic, neuromuscular disease. A
thorough understanding of its genetic cause and the availability of robust models has led to …

[HTML][HTML] Mesenchymal Stromal Cell-Derived Extracellular Vesicles for Vasculopathies and Angiogenesis: Therapeutic Applications and Optimization

Y Zhu, ZF Liao, MH Mo, XD Xiong - Biomolecules, 2023 - mdpi.com
Extracellular vesicles (EVs), as part of the cellular secretome, have emerged as essential
cell–cell communication regulators in multiple physiological and pathological processes …

[HTML][HTML] Organ-on-a-chip: an emerging research platform

R Nithin, A Aggarwal, AB Sravani, P Mallya… - Organogenesis, 2023 - ncbi.nlm.nih.gov
In drug development, conventional preclinical and clinical testing stages rely on cell cultures
and animal experiments, but these methods may fall short of fully representing human …

3D printed tubulointerstitium chip as an in vitro testing platform

G Addario, D Eussen, S Djudjaj, P Boor… - Macromolecular …, 2024 - Wiley Online Library
Chronic kidney disease (CKD) ranks as the twelfth leading cause of death worldwide with
limited treatment options. The development of in vitro models replicating defined segments …

[PDF][PDF] Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease

FAY Yengej, CP Casellas, CME Ammerlaan… - Cell Reports, 2024 - cell.com
Organoid technology is rapidly gaining ground for studies on organ (patho) physiology.
Tubuloids are long-term expanding organoids grown from adult kidney tissue or urine. The …