Pathogenicity and virulence of Staphylococcus aureus

GYC Cheung, JS Bae, M Otto - Virulence, 2021 - Taylor & Francis
Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and
mortality due to an infectious agent. This pathogen can cause a wide variety of diseases …

Staphylococcus aureus Secreted Toxins and Extracellular Enzymes

K Tam, VJ Torres - Microbiology spectrum, 2019 - Am Soc Microbiol
Staphylococcus aureus is a formidable pathogen capable of causing infections in different
sites of the body in a variety of vertebrate animals, including humans and livestock. A major …

Exploring the Role of Staphylococcus aureus in Inflammatory Diseases

H Chen, J Zhang, Y He, Z Lv, Z Liang, J Chen, P Li… - Toxins, 2022 - mdpi.com
Staphylococcus aureus is a very common Gram-positive bacterium, and S. aureus infections
play an extremely important role in a variety of diseases. This paper describes the types of …

Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion

AJ Laarman, M Ruyken, CL Malone… - The Journal of …, 2011 - journals.aai.org
Complement is one of the first host defense barriers against bacteria. Activated complement
attracts neutrophils to the site of infection and opsonizes bacteria to facilitate phagocytosis …

Corruption of innate immunity by bacterial proteases

J Potempa, RN Pike - Journal of innate immunity, 2009 - karger.com
The innate immune system of the human body has developed numerous mechanisms to
control endogenous and exogenous bacteria and thus prevent infections by these …

Extracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence‐determinant stability

SL Kolar, J Antonio Ibarra, FE Rivera… - …, 2013 - Wiley Online Library
Staphylococcus aureus is a highly virulent and successful pathogen that causes a diverse
array of diseases. Recently, an increase of severe infections in healthy subjects has been …

Intracellular Staphylococcus aureus and host cell death pathways

YM Soe, S Bedoui, TP Stinear… - Cellular …, 2021 - Wiley Online Library
Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent.
Although S. aureus and humans may have co‐evolved to the point of commensalism, the …

Bacterial proteases and virulence

D Frees, L Brøndsted, H Ingmer - Regulated proteolysis in microorganisms, 2013 - Springer
Bacterial pathogens rely on proteolysis for variety of purposes during the infection process.
In the cytosol, the main proteolytic players are the conserved Clp and Lon proteases that …

Phagocytosis of Staphylococcus aureus by Macrophages Exerts Cytoprotective Effects Manifested by the Upregulation of Antiapoptotic Factors

J Koziel, A Maciag-Gudowska, T Mikolajczyk… - PloS one, 2009 - journals.plos.org
It is becoming increasingly apparent that Staphylococcus aureus are able to survive
engulfment by macrophages, and that the intracellular environment of these host cells …

Staphylococcal proteases aid in evasion of the human complement system

M Jusko, J Potempa, T Kantyka, E Bielecka… - Journal of innate …, 2014 - karger.com
Staphylococcus aureus is an opportunistic pathogen that presents severe health care
concerns due to the prevalence of multiple antibiotic-resistant strains. New treatment …