Sphingolipids are a specialized group of lipids essential to the composition of the plasma
membrane of many cell types; however, they are primarily localized within the nervous …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

Excessive airway obstruction is the cause of symptoms and abnormal lung function in
asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is …

Both structural and inflammatory cells are capable of secreting transforming growth factor
(TGF)‐β and expressing TGF‐β receptors. TGF‐β can induce multiple cellular responses …

Sphingolipids are formed via the metabolism of sphingomyelin, a constituent of the plasma
membrane, or by de novo synthesis. Enzymatic pathways result in the formation of several …

Increased airway smooth muscle (ASM) mass is perhaps the most important component of
the airway wall remodeling process in asthma. Known mediators of ASM proliferation in cell …

Increased airway smooth muscle (ASM) mass is a feature of asthmatic airways, and could
result from augmented proliferation. We determined whether proliferation and IL-6 release …

Chronic degenerative inflammatory diseases, such as chronic obstructive pulmonary
disease and Alzheimer's dementia, afflict millions of people around the world, causing death …

Abstract Cysteinyl‐leukotrienes (cysteinyl‐LTs), that is, LTC4, LTD4, and LTE4, trigger
contractile and inflammatory responses through the specific interaction with G protein …

Asthma is characterised by airway hyperresponsiveness, airway inflammation and airway
remodelling. Airway smooth muscle cells are known to be the main effector cells of airway …