Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …

Transepithelial Cl− and HCO3− transport is critically important for the function of all epithelia
and, when altered or ablated, leads to a number of diseases, including cystic fibrosis …

The intestine exerts a considerable influence over urinary oxalate in two ways, through the
absorption of dietary oxalate and by serving as an adaptive extra-renal pathway for …

Background The transport of transepithelial Cl-and HCO3-is crucial for the function of the
intestinal epithelium and maintains the acid-based homeostasis. Slc26a3 (DRA), as a key …

Enteropathogenic E. coli (EPEC) is a major cause of infantile diarrhea, but the
pathophysiology underlying associated diarrhea is poorly understood. We examined the …

Solute Carrier Family 26 (SLC26) is a conserved anion transporter family with 10 members
in human (SLC26A1-A11, A10 being a pseudogene). All SLC26 genes except for SLC26A5 …

Background & Aims SLC26A3 (DRA) is an electroneutral Cl-/HCO 3-exchanger that is
present in the apical domain of multiple intestinal segments. An area that has continued to …

The mixing of gastric and pancreatic juice subjects the jejunum to unique ionic conditions
with high luminal CO 2 tension and HCO 3− concentration. We investigated the role of the …

Abstract Aim SLC26A3 (DRA) mediates the absorption of luminal Cl− in exchange for
HCO3− in the distal intestine. Its expression is lost in congenital chloride diarrhoea (CLD) …

ABSTRACT SLC26 family members are multifunctional transporters of small anions,
including Cl−, HCO3−, sulfate, oxalate, and formate. Most SLC26 isoforms act as secondary …