Background This review updates part of an earlier Cochrane Review titled" Pregabalin for
acute and chronic pain in adults", and considers only neuropathic pain (pain from damage to …

Background A 2017 systematic review (SR) identified 59 studies examining gabapentinoid
(pregabalin and gabapentin) misuse/abuse. Evidence of gabapentinoid misuse/abuse has …

Background Gabapentin is commonly used to treat neuropathic pain (pain due to nerve
damage). This review updates a review published in 2014, and previous reviews published …

In the last ten years, gabapentin and pregabalin have been becoming dispensed broadly
and sold on black markets, thereby, exposing millions to potential side-effects. Meanwhile …

Due to the physiological and structural properties of the blood–brain barrier (BBB), the
delivery of drugs to the brain poses a unique challenge in patients with central nervous …

Opioid Tolerance in Critical Illness | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Temporomandibular joint (TMJ) disorders refers to multietiological conditions defined by
pain and/or loss of function of the TMJ, the muscles of mastication, and other associated …

Background: Marijuana extracts (cannabinoids) have been used for several millennia for
pain treatment. Regarding the site of action, cannabinoids are highly promiscuous …

Anti-epileptic drugs (AEDs) are an important group of drugs of several generations, ranging
from the oldest phenobarbital (1912) to the most recent cenobamate (2019). Cannabidiol …

Abstract Background North America continues to face an opioid overdose epidemic, driven
by persistent increases in illicit fentanyls and fluctuations in potency leading to uncertainty …