Pathological cardiac hypertrophy may be associated with reduced expression of glucose
transporter 4 (GLUT4) in contrast to exercise-induced cardiac hypertrophy, where GLUT4 …

Cardiovascular disease (CVD) is the leading cause of death in most developed countries.
Aging is associated with enhanced risk of CVD. Insulin-like growth factor-1 (IGF-1) binds to …

Aims To examine the role of physiological Akt signalling in pathological hypertrophy through
analysis of PHLPP1 (PH domain leucine-rich repeat protein phosphatase) knock-out (KO) …

The multidomain protein encoded by the Tumor Susceptibility Gene 101 (TSG101) is
ubiquitously expressed and is suggested to function in diverse intracellular processes. In …

Exercise is the archetype of physiologic demands placed on the cardiovascular system.
Acute responses provide an informative assessment of cardiovascular function and fitness …

The leading cause of heart failure is cardiomyopathy and damage to the cardiomyocytes.
Adult mammalian cardiomyocytes have the ability to regenerate, but this cannot wholly …

Preeclampsia is the major cause of maternofetal and neonatal morbi-mortality including
intrauterine growth retardation, miscarriages and stillbirths. Inadequate vascular dilation and …

Swim-training exercise in mice leads to cardiac remodeling associated with an improvement
in contractile function. Protein O-linked N-acetylglucosamine (O-GlcNAcylation) is a …

The insulin-like growth factor 1 receptor (IGF1R) and phosphoinositide 3-kinase p110α
(PI3K) are critical regulators of exercise-induced physiological cardiac hypertrophy and …

Exercise training is recognized to improve cardiac and skeletal muscle mitochondrial
respiratory capacity; however, the impact of chronic exercise on vascular mitochondrial …