[HTML][HTML] Human placental development and function

T Cindrova-Davies, AN Sferruzzi-Perri - Seminars in cell & developmental …, 2022 - Elsevier
The placenta is a transient fetal organ that plays a critical role in the health and wellbeing of
both the fetus and its mother. Functionally, the placenta sustains the growth of the fetus as it …

[HTML][HTML] Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia

R Marín, DI Chiarello, C Abad, D Rojas… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

Placental function in maternal obesity

AC Kelly, TL Powell, T Jansson - Clinical Science, 2020 - portlandpress.com
Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …

Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

A Colson, P Sonveaux, F Debiève… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Immunoendocrine dysregulation during gestational diabetes mellitus: The central role of the placenta

A Olmos-Ortiz, P Flores-Espinosa, L Díaz… - International Journal of …, 2021 - mdpi.com
Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by
dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and …

[HTML][HTML] Placental energy metabolism in health and disease—significance of development and implications for preeclampsia

ILMH Aye, CE Aiken, DS Charnock-Jones… - American journal of …, 2022 - Elsevier
The placenta is a highly metabolically active organ fulfilling the bioenergetic and
biosynthetic needs to support its own rapid growth and that of the fetus. Placental metabolic …

Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy

JJ Fisher, LA Bartho, AV Perkins… - Clinical and …, 2020 - Wiley Online Library
Mitochondria are central to cell function. The placenta forms the interface between maternal
and fetal systems, and placental mitochondria have critical roles in maintaining pregnancy …

Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth

P Hofstee, LA Bartho, DR McKeating… - The Journal of …, 2019 - Wiley Online Library
Key points Inappropriate intake of key micronutrients in pregnancy is known to alter maternal
endocrine status, impair placental development and induce fetal growth restriction …

Hypoxia and mitochondrial dysfunction in pregnancy complications

XQ Hu, L Zhang - Antioxidants, 2021 - mdpi.com
Hypoxia is a common and severe stress to an organism's homeostatic mechanisms, and
hypoxia during gestation is associated with significantly increased incidence of maternal …

Placental mitochondrial function and dysfunction in preeclampsia

F Jahan, G Vasam, AE Green, SA Bainbridge… - International journal of …, 2023 - mdpi.com
The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational
parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in …