Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function
The purpose of this paper is to provide an integrative review and offer novel insights
regarding human research with classic psychedelics (classic hallucinogens), which are …
regarding human research with classic psychedelics (classic hallucinogens), which are …
Ketamine: a paradigm shift for depression research and treatment
Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-
resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of …
resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of …
Lower synaptic density is associated with depression severity and network alterations
SE Holmes, D Scheinost, SJ Finnema… - Nature …, 2019 - nature.com
Synaptic loss and deficits in functional connectivity are hypothesized to contribute to
symptoms associated with major depressive disorder (MDD) and post-traumatic stress …
symptoms associated with major depressive disorder (MDD) and post-traumatic stress …
Serotonin and neuroplasticity–links between molecular, functional and structural pathophysiology in depression
Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both
systems likewise contribute to pathophysiology of depression. Recent findings demonstrate …
systems likewise contribute to pathophysiology of depression. Recent findings demonstrate …
Advancing understanding of executive function impairments and psychopathology: bridging the gap between clinical and cognitive approaches
Executive function (EF) is essential for successfully navigating nearly all of our daily
activities. Of critical importance for clinical psychological science, EF impairments are …
activities. Of critical importance for clinical psychological science, EF impairments are …
The effect of intravenous, intranasal, and oral ketamine in mood disorders: a meta-analysis
RS McIntyre, IP Carvalho, LMW Lui, A Majeed… - Journal of affective …, 2020 - Elsevier
Background Ketamine is established as a rapid and effective treatment in adults with
treatment-resistant depression (TRD). The availability of different formulations and routes of …
treatment-resistant depression (TRD). The availability of different formulations and routes of …
Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory
Emotional arousal enhances perception and memory of high-priority information but impairs
processing of other information. Here, we propose that, under arousal, local glutamate levels …
processing of other information. Here, we propose that, under arousal, local glutamate levels …
Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies
S Moriguchi, A Takamiya, Y Noda, N Horita… - Molecular …, 2019 - nature.com
Alterations in glutamatergic neurotransmission are implicated in the pathophysiology of
depression, and the glutamatergic system represents a treatment target for depression. To …
depression, and the glutamatergic system represents a treatment target for depression. To …
R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects
Although the efficacy of racemate ketamine, a rapid onset and sustained antidepressant, for
patients with treatment-resistant depression was a serendipitous finding, clinical use of …
patients with treatment-resistant depression was a serendipitous finding, clinical use of …