[HTML][HTML] Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics

H Lu, Y Jing, C Zhang, S Ma, W Zhang, D Huang… - Protein & Cell, 2024 - ncbi.nlm.nih.gov
The ovary is indispensable for female reproduction, and its age-dependent functional
decline is the primary cause of infertility. However, the molecular basis of ovarian aging in …

[HTML][HTML] Single-cell transcriptomics analysis of human small antral follicles

X Fan, I Moustakas, M Bialecka, JS Del Valle… - International journal of …, 2021 - mdpi.com
Human ovarian folliculogenesis is a highly regulated and complex process. Characterization
of follicular cell signatures during this dynamic process is important to understand follicle …

[HTML][HTML] Classification of Atretic Small Antral Follicles in the Human Ovary

F Wei, X Fan, JS Del Valle, JD Asseler… - International journal of …, 2023 - mdpi.com
The reproductive lifespan in humans is regulated by a delicate cyclical balance between
follicular recruitment and atresia in the ovary. The majority of the small antral follicles present …

[HTML][HTML] Dynamic in vitro culture of cryopreserved-thawed human ovarian cortical tissue using a microfluidics platform does not improve early folliculogenesis

JS Del Valle, V Mancini, M Laverde Garay… - Frontiers in …, 2022 - frontiersin.org
Current strategies for fertility preservation include the cryopreservation of embryos, mature
oocytes or ovarian cortical tissue for autologous transplantation. However, not all patients …

Ovarian stimulation with excessive FSH doses causes cumulus cell and oocyte dysfunction in small ovarian reserve heifers

KR Karl, PZ Schall, ZL Clark, ML Ruebel… - Molecular Human …, 2023 - academic.oup.com
Excessive FSH doses during ovarian stimulation in the small ovarian reserve heifer (SORH)
cause premature cumulus expansion and follicular hyperstimulation dysgenesis (FHD) in …

RNA sequencing and expression analysis reveal a role for Lhx9 in the haploinsufficient adult mouse ovary

S Workman, MJ Wilson - Molecular Reproduction and …, 2023 - Wiley Online Library
Understanding the molecular pathways that underpin ovarian development and function is
vital for improving the research approaches to investigating fertility. Despite a significant …

Vitrification alters growth differentiation factor 9 and follicle-stimulating hormone receptor expression in human cumulus-mural granulosa cells

BI Sirait, B Wiweko, N Handayani, AM Sundari… - CERM, 2024 - repository.uki.ac.id
Objective: Ovarian tissue vitrification is widely utilized for fertility preservation in prepubertal
and adolescent female patients with cancer. The current literature includes reports of …

Akr1b7 functions as a master regulator in ovarian aging

K Isayama, K Watanabe, M Ohtsuka, S Kimura… - bioRxiv, 2023 - biorxiv.org
At the beginning of ovarian aging, the ovulation of immature oocytes is accelerated, leading
to the arrest of ovulation despite the remaining oocytes. Here, RNA expression in the …

[PDF][PDF] Lhx9: a key factor in ovarian function from development to maturity

SE Workman - 2022 - ourarchive.otago.ac.nz
Despite an incredible improvement in our understanding of the genetic mechanisms
regulating mammalian reproductive development and ovarian function, there remain an …

[PDF][PDF] Decoding the molecular makeup of the human o ar through single-cell transcriptomics

X Fan - BioEssays - scholarlypublications …
Sexual reproduction is a common feature of multicellular eukaryotic species, involving the
fusion of two haploid gametes to transmit genetic information between generations. In …