The study of pain in awake animals raises ethical, philosophical, and technical problems.
We review the ethical standards for studying pain in animals and emphasize that there are …

The aim of the current study was to adapt the orofacial formalin pain model previously
developed in rats for use in mice and to characterize as fully as possible the behavioral …

A quantitative structure–activity relationship (QSAR) analysis of a series of arylpropionic acid
non‐steroidal anti‐inflammatory drugs (NSAIDs) has been performed to determine which …

We have previously shown in rats that both intrathecal and systemic analgesia regimens
attenuate surgery-induced increases in tumor susceptibility. The current study used …

The mechanism of action of acetaminophen is currently widely discussed. Direct inhibition of
cyclooxygenase isoforms remains the commonly advanced hypothesis. We combined …

A C-fiber reflex elicited by electrical stimulation within the territory of the sural nerve was
recorded from the ipsilateral biceps femoris muscle in anesthetized rats. The temporal …

Objective To analyze the anti-inflammatory and analgesic effects of an adhesive resin
containing indomethacin-loaded nanocapsules in rat model. Design Adhesive resin disks …

In view of the widespread use of non-steroidal anti-inflammatory drugs for treatment of
inflammatory pain, we determined the effects of the non-steroidal anti-inflammatory drug …

In addition to effects in the periphery through inhibition of prostaglandin synthesis, several
lines of evidence suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) act in the …

This electrophysiological study examined the effects of NSAID administration on synaptically-
elicited responses of rat single spinal dorsal horn neurons to natural stimulation of …