[HTML][HTML] Challenges and opportunities for global genomic surveillance strategies in the COVID-19 era
Global SARS-CoV-2 genomic surveillance efforts have provided critical data on the ongoing
evolution of the virus to inform best practices in clinical care and public health throughout the …
evolution of the virus to inform best practices in clinical care and public health throughout the …
[HTML][HTML] SARS-CoV-2 variants identification: overview of molecular existing methods
Since the beginning of COVID-19 pandemic the Real Time sharing of genome sequences of
circulating virus supported the diagnostics and surveillance of SARS-CoV-2 and its …
circulating virus supported the diagnostics and surveillance of SARS-CoV-2 and its …
Rapid detection of the Omicron (B. 1.1. 529) SARS-CoV-2 variant using a COVID-19 diagnostic PCR assay
C Ippoliti, F De Maio, G Santarelli… - Microbiology …, 2022 - Am Soc Microbiol
ABSTRACT The Omicron (B. 1.1. 529) variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is the last variant of concern (VOC) identified to date …
coronavirus 2 (SARS-CoV-2) is the last variant of concern (VOC) identified to date …
A simulation framework for modeling the within-patient evolutionary dynamics of SARS-CoV-2
The global impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
led to considerable interest in detecting novel beneficial mutations and other genomic …
led to considerable interest in detecting novel beneficial mutations and other genomic …
[HTML][HTML] Whole-genome sequencing to investigate transmission of SARS-CoV-2 in the acute healthcare setting: a systematic review
Background Whole-genome sequencing (WGS) has been used widely to elucidate
transmission of SARS-CoV-2 in acute healthcare settings, and to guide Infection, Prevention …
transmission of SARS-CoV-2 in acute healthcare settings, and to guide Infection, Prevention …
Sensitivity of detection and variant typing of SARS-CoV-2 in European laboratories
R Mögling, C Fischer, KR Stanoeva… - Journal of Clinical …, 2022 - Am Soc Microbiol
The molecular detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
is key for clinical management and surveillance. Funded by the European Centre for …
is key for clinical management and surveillance. Funded by the European Centre for …
[HTML][HTML] Geneticin shows selective antiviral activity against SARS-CoV-2 by interfering with programmed− 1 ribosomal frameshifting
SARS-CoV-2 is currently causing an unprecedented pandemic. While vaccines are
massively deployed, we still lack effective large-scale antiviral therapies. In the quest for …
massively deployed, we still lack effective large-scale antiviral therapies. In the quest for …
[HTML][HTML] Minimal requirements for ISO15189 validation and accreditation of three next generation sequencing procedures for SARS-CoV-2 surveillance in clinical …
C Maschietto, G Otto, P Rouzé, N Debortoli, B Bihin… - Scientific reports, 2023 - nature.com
Rapid and recurrent breakthroughs of new SARS-CoV-2 strains (variants) have prompted
public health authorities worldwide to set up surveillance networks to monitor the circulation …
public health authorities worldwide to set up surveillance networks to monitor the circulation …
[HTML][HTML] SPLASH: a statistical, reference-free genomic algorithm unifies biological discovery
Today's genomics workflows typically require alignment to a reference sequence, which
limits discovery. We introduce a unifying paradigm, SPLASH (Statistically Primary aLignment …
limits discovery. We introduce a unifying paradigm, SPLASH (Statistically Primary aLignment …
[HTML][HTML] Predicting COVID-19 disease severity from SARS-CoV-2 spike protein sequence by mixed effects machine learning
BA Sokhansanj, GL Rosen - Computers in biology and medicine, 2022 - Elsevier
Epidemiological studies show that COVID-19 variants-of-concern, like Delta and Omicron,
pose different risks for severe disease, but they typically lack sequence-level information for …
pose different risks for severe disease, but they typically lack sequence-level information for …