Global SARS-CoV-2 genomic surveillance efforts have provided critical data on the ongoing
evolution of the virus to inform best practices in clinical care and public health throughout the …

Since the beginning of COVID-19 pandemic the Real Time sharing of genome sequences of
circulating virus supported the diagnostics and surveillance of SARS-CoV-2 and its …

ABSTRACT The Omicron (B. 1.1. 529) variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is the last variant of concern (VOC) identified to date …

The global impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
led to considerable interest in detecting novel beneficial mutations and other genomic …

Background Whole-genome sequencing (WGS) has been used widely to elucidate
transmission of SARS-CoV-2 in acute healthcare settings, and to guide Infection, Prevention …

The molecular detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
is key for clinical management and surveillance. Funded by the European Centre for …

SARS-CoV-2 is currently causing an unprecedented pandemic. While vaccines are
massively deployed, we still lack effective large-scale antiviral therapies. In the quest for …

Rapid and recurrent breakthroughs of new SARS-CoV-2 strains (variants) have prompted
public health authorities worldwide to set up surveillance networks to monitor the circulation …

Today's genomics workflows typically require alignment to a reference sequence, which
limits discovery. We introduce a unifying paradigm, SPLASH (Statistically Primary aLignment …

Epidemiological studies show that COVID-19 variants-of-concern, like Delta and Omicron,
pose different risks for severe disease, but they typically lack sequence-level information for …