Immune tolerance deletes or suppresses autoreactive lymphocytes and is established at
multiple levels during the development, activation and effector phases of T and B cells …

Recent clinical trials in people with type 2 diabetes have demonstrated beneficial actions on
heart and kidney outcomes following treatment with GLP-1RAs. In part, these actions are …

Inflammation contributes to many chronic conditions. It is often associated with circulating
pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity …

Methods| We used the TriNetX platform to access deidentified electronic health records of
101.2 million patients, including 7.4 million with T2D from 59 health care organizations …

Diabetic kidney disease (DKD) is the first cause of end-stage kidney disease in patients with
diabetes and its prevalence is increasing worldwide. It encompasses histological alterations …

It is well established that decreases in plasma leptin levels, as with fasting, signal starvation
and elicit appropriate physiological responses, such as increasing the drive to eat and …

Aims SURE Italy, a multicentre, prospective, open‐label, observational, real‐world study,
investigated once‐weekly semaglutide in patients with type 2 diabetes (T2D) in routine …

The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin
effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also …

The excessive intake of fructose in the regular human diet could be related to global
increases in metabolic disorders. Sugar-sweetened soft drinks, mostly consumed by …

Macrophages play diverse roles in development, homeostasis, and immunity. Accordingly,
the dysfunction of macrophages is involved in the occurrence and progression of various …