Simple Summary T cells are immune cells that can be used to target infections or cancers.
Adoptive T-cell immunotherapy leverages these properties and/or confers new features to T …

Memory CD8+ T cells in the immune system are responsible for the removal of external Ags
for a long period of time to protect against re-infection. Naïve to memory CD8+ T cell …

Secondary lymphoid organs (SLO), including the spleen and lymph nodes (LN) are a
meeting place for immune cells to initiate adaptive immune responses. Lymphocytes …

CC receptor 7 (CCR7) is important to allow T cells and dendritic cells to migrate toward
CCL19-and CCL21-producing cells in the T-cell zone of the spleen and lymph nodes. The …

The relationship between the extrinsic environment and the internal transcriptional network
is circular. Naive T cells first engage with antigen‐presenting cells to set transcriptional …

The inflammatory status of the tumor microenvironment (TME) has been heavily investigated
in recent years. Chemokine-and cytokine-signaling pathways such as CCR7, CXCR5 …

The activation of naive CD8 T cells typically results in the formation of effector cells (TE) as
well as phenotypically distinct memory cells that are retained over time. Memory CD8 T cells …

Abstract Effector T cells (T EFF) are a barrier to booster vaccination because they can rapidly
kill Ag-bearing APCs before memory T cells are engaged. We report in this study that iv …

CD8+ T cells play a crucial role in the clearance of intracellular pathogens through the
generation of cytotoxic effector cells that eliminate infected cells and long-lived memory cells …

Immunological memory, defined as the ability to respond in an enhanced manner upon
secondary encounter with the same pathogen, can provide substantial protection against …