Naïve CD8+ T lymphocytes responding to microbial pathogens give rise to effector T cells
that provide acute defense and memory T cells that provide long-lived immunity. Upon …

The fate of F oxp3+ regulatory T (T reg) cells responding during autoimmunity is not well
defined. We observed a marked elevation in KLRG 1+(where KLRG1 stands for killer cell …

Abstract Sphingosine-1-phosphate (S1P) plays an important role in trafficking leukocytes
and developing immune disorders including autoimmunity. In the synovium of rheumatoid …

Understanding the mechanisms that regulate the differentiation and maintenance of CD8+
memory T cells is fundamental to the development of effective T cell-based vaccines …

Immune-mediated liver injury is a central feature of hyperinflammatory diseases, such as
hemophagocytic syndromes, yet the immunologic mechanisms underlying those processes …

Androgen-disrupting chemicals (ADCs) can alter male sexual development. Although the
effects of ADCs on hormone disruption have been studied, their influence on the immune …

Increased demand for novel, highly effective vaccination strategies necessitates a better
understanding of long-lived memory CD8 T cell differentiation. To achieve this …

Mucosal HSV infection remains a public health issue in developing and developed world.
However, an effective vaccine is still missing, partly because of the incomplete knowledge of …

Memory T (TM) cells play an important role in the long-term defense against pathogen
reinvasion. However, it is still unclear how these cells receive the crucial signals necessary …

Myeloid-derived suppressor cells (MDSCs) represent a major population controlling T cell
immune responses. However, little is known about their molecular requirements for homing …