Role of virus-related chronic inflammation and mechanisms of cancer immune-suppression in pathogenesis and progression of hepatocellular carcinoma

M Borgia, M Dal Bo, G Toffoli - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma pathogenesis is dependent on a chronic
inflammation caused by several factors, including hepatotropic viruses, such as HCV and …

Retinoids in the pathogenesis and treatment of liver diseases

M Melis, XH Tang, SE Trasino, LJ Gudas - Nutrients, 2022 - mdpi.com
Vitamin A (VA), all-trans-retinol (ROL), and its analogs are collectively called retinoids.
Acting through the retinoic acid receptors RARα, RARβ, and RARγ, all-trans-retinoic acid, an …

Effect of silymarin on the relative gene expressions of some inflammatory cytokines in the liver of CCl4-intoxicated male rats

SM El-Kot, W Wanas, AM Hafez, NA Mahmoud… - Scientific Reports, 2023 - nature.com
The intensive exposure of the liver cells to any type of noxae, such as viruses, drugs,
alcohols, and xenobiotics could induce hepatic inflammation through the upregulation of …

Hepatitis C virus in pregnancy: an opportunity to test and treat

RS Fogel, CA Chappell - Obstetrics and Gynecology Clinics, 2023 - obgyn.theclinics.com
An estimated 15 million people of childbearing potential have chronic hepatitis C virus
(HCV) and are at risk for the development of cirrhosis and hepatocellular carcinoma. 1 …

Viral hepatitis and hepatocellular carcinoma: State of the art

T Datfar, M Doulberis, A Papaefthymiou, IN Hines… - Pathogens, 2021 - mdpi.com
Viral hepatitis is one of the main causes leading to hepatocellular carcinoma (HCC). The
continued rise in incidence of HCC suggests additional factors following infection may be …

CCl4‐Induced Liver Injury Was Ameliorated by Qi‐Ge Decoction through the Antioxidant Pathway

C Peng, Z Zhou, J Li, Y Luo, Y Zhou… - Evidence‐Based …, 2019 - Wiley Online Library
Qi‐Ge decoction (QGD), which is derived from the Huangqi Gegen decoction, contains three
traditional Chinese herbs: Astragalus membranaceus (Huangqi), Pueraria lobata (Gegen) …

[HTML][HTML] The Role of Mitochondrial Dysfunction in the Development of Acute and Chronic Hepatitis С

A Blagov, V Sukhorukov, V Orekhova… - Frontiers in Bioscience …, 2023 - imrpress.com
Currently, the issue relating to the discussion raised in this article appears to be for what
purposes the hepatitis C virus (HCV) modulates cellular processes, such as antiviral …

[HTML][HTML] TNF-alpha inhibition ameliorates HDV-induced liver damage in a mouse model of acute severe infection

C Usai, S Maestro, G Camps, C Olague… - JHEP reports, 2020 - Elsevier
Background & Aims HDV infection induces the most severe form of human viral hepatitis.
However, the specific reasons for the severity of the disease remain unknown. Recently, we …

Proteomics reveals a global phenotypic shift of NK cells in HCV patients treated with direct‐acting antivirals

W Bi, A Kraft, S Engelskircher, J Mischke… - European Journal of …, 2023 - Wiley Online Library
Chronic hepatitis C virus (HCV) infections compromise natural killer (NK)‐cell immunity.
Direct‐acting antivirals (DAA) effectively eliminate HCV, but the long‐term effects on NK …

Risk factors contributing to the occurrence and recurrence of hepatocellular carcinoma in hepatitis C virus patients treated with direct-acting antivirals

S Kishta, A Tabll, T Omanovic Kolaric, R Smolic… - Biomedicines, 2020 - mdpi.com
Although hepatitis C virus (HCV) RNA may be eliminated from blood circulation by direct-
acting antivirals (DAA) therapy as assessed by real-time polymerase chain reaction (PCR) …