Cancer-associated cachexia—understanding the tumour macroenvironment and microenvironment to improve management

JM Argilés, FJ López-Soriano, B Stemmler… - Nature Reviews …, 2023 - nature.com
Cachexia is a devastating, multifactorial and often irreversible systemic syndrome
characterized by substantial weight loss (mainly of skeletal muscle and adipose tissue) that …

Adverse effects of systemic cancer therapy on skeletal muscle: myotoxicity comes out of the closet

P Klassen, DL Schiessel… - Current Opinion in Clinical …, 2023 - journals.lww.com
The adverse side effect of cancer therapy on skeletal muscle has been largely ignored in the
development of cancer therapeutics. Given the extent to which loss of muscle mass and …

[HTML][HTML] Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia

TT Vu, K Kim, M Manna, J Thomas, BC Remaily… - Pharmacological …, 2024 - Elsevier
High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or
systemic exposure, is associated with cachexia and poor outcomes in cancer patients …

Transcriptomic and proteomic time-course analyses based on Metascape reveal mechanisms against muscle atrophy in hibernating Spermophilus dauricus

K Dang, HMU Farooq, J Dong, H Yang, Y Kong… - … and Physiology Part A …, 2023 - Elsevier
Hibernating Spermophilus dauricus is resistant to muscle atrophy. Comprehensive
transcriptome and proteome time-course analyses based on Metascape can further reveal …

[PDF][PDF] Cancer-related cachexia: insight for a multimodal approach

G Mangano, F BUCCHIERI - 2023 - iris.unipa.it
Cachexia is a common complication in cancer patients, characterized by involuntary weight
loss and reduction in muscle mass, often associated with a general feeling of weakness and …