3D cell culture is an urgent requirement for large-scale cell manufacture and structure-based
tissue engineering; however, their preparation is still challenging due to the lack of a highly …

Directed differentiation of human pluripotent stem cells (hPSCs) into mature cells, tissues
and organs holds major promise for the development of novel approaches in regenerative …

Forced expression of defined transcriptional factors has been well documented as an
effective method for cellular reprogramming or directed differentiation. However, transgene …

Stem cells can be valuable model systems for drug discovery and modelling human
diseases as well as to investigate cellular interactions and molecular events in the early …

Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder caused by mutation in the
proteolipid protein-1 (PLP1) gene, which encodes the proteolipid protein of myelinating …

Endothelial cells (ECs) derived from pluripotent stem cells (PSCs) provide great resource for
vascular disease modeling and cell-based regeneration therapy. However, the molecular …

Translation of human pluripotent stem cell (hPSC)-derived therapies to the clinic demands
scalable, cost-effective methods for cell expansion. Culture media currently used for hPSC …

Pompe disease is an autosomal recessive inherited metabolic disease caused by deficiency
of acid α-glucosidase (GAA). Glycogen accumulation is seen in the affected organ such as …

The loss of cardiomyocytes during injury and disease can result in heart failure and sudden
death, while the adult heart has a limited capacity for endogenous regeneration and repair …

Superparamagnetic nanoparticles offer several opportunities in nanomedicine and magnetic
cell targeting. They are considered to be an extremely promising approach for the translation …