Background Lymphocyte receptor repertoires are continually shaped throughout the lifetime
of an individual in response to environmental and pathogenic exposure. Thus, they may …

In recent years, exposome research has been put forward as the next frontier for the study of
human health and disease. Exposome research entails the analysis of the totality of …

We describe a rapid and highly efficient method to generate point mutations in
Caenorhabditis elegans using direct injection of CRISPR-Cas9 ribonucleoproteins. This …

Rare diseases are an increasingly recognized source of health problems worldwide,
affecting personal and community health and a creating a substantial financial burden …

The clustered regularly interspersed palindromic repeats (CRISPR)-CRISPR-associated
protein 9 (Cas9) prokaryotic adaptive immune defense system has been co-opted as a …

Researchers planning to disclose secondary genomic findings to research participants
should strive to maximize benefits and minimize harms. Informed consent is a critical step in …

Background Noninvasive prenatal aneuploidy testing (NIPT) represents the first large-scale
clinical application of massively parallel sequencing technology. However, no NIPT …

AR Y long-term strategy would be to invest in the development of a set of large multicenter,
regional databases incorporating real-time data to generate a constantly improving …

The ability to unveil the genetic landscape of human disease at an extraordinarily detailed
resolution through high-throughput DNA sequencing promises a transformation of medical …

In recent years, exposome research has been put forward as the next frontier for the study of
human health and disease. Exposome research entails the analysis of the totality of …