Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery
Y Wang, JS Yang, M Zhao, JQ Chen, HX Xie… - Advanced Drug Delivery …, 2024 - Elsevier
Mitochondrial genome (mtDNA) independent of nuclear gene is a set of double-stranded
circular DNA that encodes 13 proteins, 2 ribosomal RNAs and 22 mitochondrial transfer …
circular DNA that encodes 13 proteins, 2 ribosomal RNAs and 22 mitochondrial transfer …
Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA
DddA-derived cytosine base editors (DdCBEs) and transcription activator-like effector
(TALE)-linked deaminases (TALEDs) catalyze targeted base editing of mitochondrial DNA …
(TALE)-linked deaminases (TALEDs) catalyze targeted base editing of mitochondrial DNA …
TALE-based organellar genome editing and gene expression in plants
JY Lin, YC Liu, YH Tseng, MT Chan, CC Chang - Plant Cell Reports, 2024 - Springer
Key message TALE-based editors provide an alternative way to engineer the organellar
genomes in plants. We update and discuss the most recent developments of TALE-based …
genomes in plants. We update and discuss the most recent developments of TALE-based …
Targeted A-to-G base editing in the organellar genomes of Arabidopsis with monomeric programmable deaminases
C Zhou, M Okuno, I Nakazato, N Tsutsumi… - Plant …, 2024 - academic.oup.com
Plastids and mitochondria are 2 intracellular organelles containing DNA-encoding partial
but essential components for their roles, photosynthesis, and respiration. Precise base …
but essential components for their roles, photosynthesis, and respiration. Precise base …
[HTML][HTML] Nucleoside deaminases: the key players in base editing toolkit
The development of nucleoside deaminase-containing base editors realized targeted single
base change with high efficiency and precision. Such nucleoside deaminases include …
base change with high efficiency and precision. Such nucleoside deaminases include …
Efficient DNA base editing via an optimized DYW-like deaminase
J Kweon, S Park, MY Jeon, K Lim, G Jang, AH Jang… - bioRxiv, 2024 - biorxiv.org
CRISPR-based cytosine base editors enable precise genome editing without inducing
double-stranded DNA breaks, yet traditionally depend on a limited selection of deaminases …
double-stranded DNA breaks, yet traditionally depend on a limited selection of deaminases …
Unconstrained Precision Mitochondrial Genome Editing with αDdCBEs
DddA-derived cytosine base editors (DdCBEs) enable the targeted introduction of C· G-to-T·
A conversions in mitochondrial DNA (mtDNA). DdCBEs are often deployed as pairs, with …
A conversions in mitochondrial DNA (mtDNA). DdCBEs are often deployed as pairs, with …