BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions

MK Fard, F Van Der Meer, P Sánchez… - Science translational …, 2017 - science.org
Investigations into brain function and disease depend on the precise classification of neural
cell types. Cells of the oligodendrocyte lineage differ greatly in their morphology, but …

The committed oligodendrocyte precursor cell, a newly‐defined intermediate progenitor cell type in oligodendroglial lineage

M Fang, L Chen, T Tang, M Qiu, X Xu - Glia, 2023 - Wiley Online Library
In the central nervous system, oligodendrocytes (OLs) produce myelin sheaths that provide
trophic support to neuronal axons and increase the propagation speed of action potential …

Culture protocol and transcriptomic analysis of murine SVZ NPCs and OPCs

NL Dittmann, P Torabi, AES Watson, SA Yuzwa… - Stem Cell Reviews and …, 2023 - Springer
The mammalian adult brain contains two neural stem and precursor (NPC) niches: the
subventricular zone [SVZ] lining the lateral ventricles and the subgranular zone [SGZ] in the …

Proteome profile of peripheral myelin in healthy mice and in a neuropathy model

SB Siems, O Jahn, MA Eichel, N Kannaiyan, LMN Wu… - Elife, 2020 - elifesciences.org
Proteome and transcriptome analyses aim at comprehending the molecular profiles of the
brain, its cell-types and subcellular compartments including myelin. Despite the relevance of …

A gene expression atlas for different kinds of stress in the mouse brain

T Flati, S Gioiosa, G Chillemi, A Mele, A Oliverio… - Scientific Data, 2020 - nature.com
Stressful experiences are part of everyday life and animals have evolved physiological and
behavioral responses aimed at coping with stress and maintaining homeostasis. However …

An in vitro model of neuronal ensembles

MA Rabadan, ED De La Cruz, SB Rao, Y Chen… - Nature …, 2022 - nature.com
Advances in 3D neuronal cultures, such as brain spheroids and organoids, are allowing
unprecedented in vitro access to some of the molecular, cellular and developmental …

Identification of Tau protein as a novel marker for maturation and pathological changes of oligodendrocytes

T Torii, Y Miyamoto, R Nakata, Y Higashi, Y Shinmyo… - Glia, 2023 - Wiley Online Library
Microtubule‐associated protein Tau is primarily expressed in axons of neurons, but also in
Olig2‐positive oligodendrocytes in adult rodent and monkey brains. In this study, we sought …

Fractalkine signaling regulates oligodendroglial cell genesis from SVZ precursor cells

AES Watson, MMA de Almeida, NL Dittmann, Y Li… - Stem cell reports, 2021 - cell.com
Neural and oligodendrocyte precursor cells (NPCs and OPCs) in the subventricular zone
(SVZ) of the brain contribute to oligodendrogenesis throughout life, in part due to direct …

[HTML][HTML] Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment

Y Xie, A Song, Y Zhu, A Jiang, W Peng, C Zhang… - Biomedicine & …, 2021 - Elsevier
Background In the present study, we aimed to investigate the effects of probucol on aging-
related hippocampus-dependent cognitive impairment and explore the potential …

[HTML][HTML] Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility

M Meijer, E Agirre, M Kabbe, CA van Tuijn, A Heskol… - Neuron, 2022 - cell.com
Multiple sclerosis (MS) is characterized by a targeted attack on oligodendroglia (OLG) and
myelin by immune cells, which are thought to be the main drivers of MS susceptibility. We …