Estrogen receptor activation and cardioprotection in ischemia reperfusion injury

AM Deschamps, E Murphy, J Sun - Trends in cardiovascular medicine, 2010 - Elsevier
Premenopausal females have a comparably lower incidence of cardiovascular disease than
their male counterparts. Although estrogen and activation of estrogen receptors (ERs) have …

Mitochondrial connexin 43 in sex-dependent myocardial responses and estrogen-mediated cardiac protection following acute ischemia/reperfusion injury

M Wang, K Smith, Q Yu, C Miller, K Singh… - Basic research in …, 2020 - Springer
Preserving mitochondrial activity is crucial in rescuing cardiac function following acute
myocardial ischemia/reperfusion (I/R). The sex difference in myocardial functional recovery …

[HTML][HTML] Intermittent hypoxia reduces infarct size in rats with acute myocardial infarction: a systematic review and meta-analysis

K Hu, W Deng, J Yang, Y Wei, C Wen, X Li… - BMC Cardiovascular …, 2020 - Springer
Background To determine whether intermittent hypoxia (IH) can reduce the infarct size (IS)
after acute myocardial infarction (AMI) in rats. Methods Articles were identified in PubMed …

Signaling via GPR30 protects the myocardium from ischemia/reperfusion injury

BR Weil, MC Manukyan, JL Herrmann, Y Wang… - Surgery, 2010 - Elsevier
BACKGROUND: Estrogen may protect against the development of cardiovascular disease.
Recently, a receptor known as GPR30 that seems to mediate estrogen's nongenomic effects …

The environmental hormone nonylphenol interferes with the therapeutic effects of G protein-coupled estrogen receptor specific agonist G-1 on murine allergic rhinitis

Y Wang, Z Gu, L Hao - International Immunopharmacology, 2020 - Elsevier
The G protein-coupled estrogen receptor (GPER) specific agonist G-1 has therapeutic
effects in patients with allergic diseases, but any role for G-1 as a therapy for inflammation …

Estrogenic impact on cardiac ischemic/reperfusion injury

S Sivasinprasasn, K Shinlapawittayatorn… - Journal of …, 2016 - Springer
The increase in cardiovascular disease and metabolic syndrome incidence following the
onset of menopause has highlighted the role of estrogen as a cardiometabolic protective …

[HTML][HTML] Estrogen therapy worsens cardiac function and remodeling and reverses the effects of exercise training after myocardial infarction in ovariectomized female …

SA Almeida, ERG Claudio, V Mengal, GA Brasil… - Frontiers in …, 2018 - frontiersin.org
There is an increase in the incidence of cardiovascular events such as myocardial infarction
(MI) after menopause. However, the use of estrogen therapy (E2) remains controversial. The …

Acute postischemic treatment with estrogen receptor-α agonist or estrogen receptor-β agonist improves myocardial recovery

ND Vornehm, M Wang, A Abarbanell, J Herrmann… - Surgery, 2009 - Elsevier
BACKGROUND: After ischemia/reperfusion (I/R) injury, female hearts demonstrate improved
functional recovery compared with male, which suggests a protective role for estrogen …

Role of Akt-dependent pathway in resveratrol-mediated cardioprotection after trauma-hemorrhage

YF Tsai, FC Liu, YT Lau, HP Yu - Journal of Surgical Research, 2012 - Elsevier
BACKGROUND: Resveratrol has been shown to have protective effects for patients in shock-
like states, and Akt (protein kinase B) is known to play a role in pro-inflammatory events in …

[HTML][HTML] Bisphenol A attenuates the therapeutic effect of the selective G protein-coupled estrogen receptor agonist G-1 on allergic rhinitis inflammation in mice

Y Wang, Z Cao, H Zhao, Z Gu - Ecotoxicology and Environmental Safety, 2022 - Elsevier
Abstract Background Bisphenol A (BPA) is found in many plastics widely used in everyday
life and affects the immune system. Previous studies found that the selective G protein …