Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

Skeletal muscle fitness and plasticity is an important determinant of human health and
disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by …

The mitochondrion is a complex organelle that serves essential roles in energy transduction,
ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network …

The heart requires fatty acids to maintain its activity. Various mechanisms regulate
myocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for …

Glucose and branched-chain amino acids (BCAAs) are essential nutrients and key
determinants of cell growth and stress responses. High BCAA level inhibits glucose …

A fine balance between uptake, storage, and the use of high energy fuels, like lipids, is
crucial in the homeostasis of different metabolic tissues. Nowhere is this balance more …

Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that
regulate various pathways that control metabolism and other cellular mechanisms. Various …

The main hallmark of myocardial substrate metabolism in cardiac hypertrophy or heart
failure is a shift from fatty acid oxidation to greater reliance on glycolysis. However, the close …

Loss of fatty acid β-oxidation (FAO) in the proximal tubule is a critical mediator of acute
kidney injury and eventual fibrosis. However, transcriptional mediators of FAO in proximal …

Ischemic cardiomyopathy (ICM) is the clinical endpoint of coronary heart disease and a
leading cause of heart failure. Despite growing demands to develop personalized …