Recently, there has been an increasing use of the cyclopropyl ring in drug development to
transition drug candidates from the preclinical to clinical stage. Important features of the …

Structural analysis of modern pharmaceutical practices allows for the identification of two
rapidly growing trends: the introduction of tailor‐made amino acids and the exploitation of …

Docking is a computational technique that samples conformations of small molecules in
protein binding sites; scoring functions are used to assess which of these conformations best …

Background and Objective There is a clinical need for new oral anticoagulants to prevent
and treat thromboembolic diseases. Given its integral role in the coagulation cascade, factor …

Although a very useful guideline for orally bioavailable small-molecule drug design, the 'rule-
of-five'(also known as 'Lipinski's rule of drug-likeness') has to some extent been …

Despite recent progress in antithrombotic therapy, there is still an unmet medical need for
safe and orally available anticoagulants. The coagulation enzyme Factor Xa (FXa) is a …

A novel continuous‐flow approach for the synthesis of fluoroalkyl‐substituted
diazomethanes has been developed. Utilizing a cheap, self‐made microreactor fluoroalkyl …

Herein we report on applications of fluorinated diazoalkanes in cycloaddition reactions, with
the emphasis on studying subtle differences between diverse fluorinated diazo compounds …

Accurately predicting relative binding affinities and biological potencies for ligands that
interact with proteins remains a significant challenge for computational chemists. Most …

Cardiovascular diseases are the major cause of mortality and morbidity in the industrialized
world, while their incidents are on fast ascendancy in developing countries. 1 According to …