The separate development of functionally intertwined lineages of lymphocytes known as B
cells and T cells is now recognized as a fundamental organizing principle of the adaptive …

The physiology of B cells is intimately connected with the function of their B‐cell receptor
(BCR). B‐cell lymphomas frequently (dys) regulate BCR signalling and thus take advantage …

Summary Phosphatidylinositol 3′ OH kinase (PI3K) signaling and FOXO transcription
factors play opposing roles at several B cell developmental stages. We show here abundant …

Despite the known importance of zinc for human immunity, molecular insights into its roles
have remained limited. Here we report a novel autosomal recessive disease characterized …

Around four decades ago, it had been observed that there were cell lines as well as cells in
the fetal liver that expressed antibody μ heavy (μH) chains in the apparent absence of bona …

Mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that coordinates
nutrient and growth factor availability with cellular growth, division, and differentiation …

Cell surface glycans and their glycan-binding partners (lectins) have generally been
recognized as adhesive assemblies with neighbor cells or matrix scaffolds in organs and the …

Bruton's tyrosine kinase (BTK) is a non-receptor kinase belonging to the Tec family of
kinases. The role of BTK in B cell receptor signaling is well defined and is known to play a …

PAX5, a member of the Paired Box (PAX) transcription factor family, is an essential factor for
B-lineage identity during lymphoid differentiation. Mechanistically, PAX5 controls gene …

The development and function of B lymphocytes is regulated by numerous signaling
pathways, some emanating from the B‐cell antigen receptor (BCR). The spleen tyrosine …