Fundamentals of redox regulation in biology

H Sies, RJ Mailloux, U Jakob - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of
oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular …

[HTML][HTML] Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications

B Kalyanaraman, G Cheng, M Hardy - Redox Biology, 2024 - Elsevier
In this review, we explore how short-chain fatty acids (SCFAs) produced by the gut
microbiome affect Parkinson's disease (PD) through their modulatory interactions with alpha …

The effect of probiotic supplementation on the clinical and Para-clinical findings of multiple sclerosis: a randomized clinical trial

KM Asghari, N Dolatkhah, H Ayromlou, F Mirnasiri… - Scientific Reports, 2023 - nature.com
Multiple Sclerosis (MS) is a chronic demyelination disease of the central nervous system
(CNS). The gut-brain axis involves communication between the nervous, endocrine, and …

Flaxseed lignan alleviates the paracetamol-induced hepatotoxicity associated with regulation of gut microbiota and serum metabolome

Y Ren, Z Xu, Z Qiao, X Wang, C Yang - Nutrients, 2024 - mdpi.com
This study examined the protective effect of flaxseed lignans on liver damage caused by an
overdose of paracetamol (PAM). The findings demonstrated that administering 800 mg/kg/d …

Trihexyphenidyl Alters Its Host's Metabolism, Neurobehavioral Patterns, and Gut Microbiome Feedback Loop—The Modulating Role of Anacyclus pyrethrum

A Baslam, H Azraida, R Aboufatima, M Ait-El-Mokhtar… - Antioxidants, 2023 - mdpi.com
Trihexyphenidyl (THP)—a synthetic anticholinergic medication used to manage
parkinsonism and extrapyramidal symptoms—has gained significant clinical recognition …

Gastrointestinal redox homeostasis in ageing

J Homolak - Biogerontology, 2023 - Springer
The gastrointestinal (GI) barrier acts as the primary interface between humans and the
external environment. It constantly faces the risk of inflammation and oxidative stress due to …

Bergamot polyphenolic extract combined with albedo and pulp fibres counteracts changes in gut microbiota associated with high-fat diet: implications for lipoprotein …

R Mollace, R Macrì, M Nicita, V Musolino… - International Journal of …, 2023 - mdpi.com
Evidence exists that the gut microbiota contributes to the alterations of lipid metabolism
associated with high-fat diet (HFD). Moreover, the gut microbiota has been found to …

The AKI-to-CKD Transition: The Role of Uremic Toxins

C André, S Bodeau, S Kamel, Y Bennis… - International Journal of …, 2023 - mdpi.com
After acute kidney injury (AKI), renal function continues to deteriorate in some patients. In a
pro-inflammatory and profibrotic environment, the proximal tubules are subject to …

Gut Microbiome-Mediated Mechanisms in Alleviating Opioid Addiction with Aqueous Extract of Anacyclus pyrethrum

A Baslam, H Kabdy, Y Chait, H Azraida, L El Yazouli… - Biomedicines, 2024 - mdpi.com
The escalating rates of morbidity and mortality associated with opioid use disorder (OUD)
have spurred a critical need for improved treatment outcomes. This study aimed to …

Probiotics—role in alleviating the impact of alcohol liver disease and alcohol deaddiction: a systematic review

G Vidya Bernhardt, P Shivappa, J R. Pinto, R Ks… - Frontiers in …, 2024 - frontiersin.org
Background There are few efficient treatment options for alcohol addiction, which continues
to be a serious public health concern. The possible contribution of gut microbiota to the …