Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism

GA Dienel, NF Cruz - Journal of neurochemistry, 2016 - Wiley Online Library
Aerobic glycolysis occurs during brain activation and is characterized by preferential up‐
regulation of glucose utilization compared with oxygen consumption even though oxygen …

Glial connexins and pannexins in the healthy and diseased brain

C Giaume, CC Naus, JC Sáez… - Physiological …, 2021 - journals.physiology.org
Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission

DL Rothman, GA Dienel, KL Behar… - Journal of Cerebral …, 2022 - journals.sagepub.com
Over the last two decades, it has been established that glucose metabolic fluxes in neurons
and astrocytes are proportional to the rates of the glutamate/GABA-glutamine …

Potential new roles for glycogen in epilepsy

GA Dienel, L Gillinder, A McGonigal, K Borges - Epilepsia, 2023 - Wiley Online Library
Seizures often originate in epileptogenic foci. Between seizures (interictally), these foci and
some of the surrounding tissue often show low signals with 18fluorodeoxyglucose (FDG) …

Gray and white matter astrocytes differ in basal metabolism but respond similarly to neuronal activity

S Köhler, U Winkler, T Junge, K Lippmann, J Eilers… - Glia, 2023 - Wiley Online Library
Astrocytes are a heterogeneous population of glial cells in the brain, which adapt their
properties to the requirements of the local environment. Two major groups of astrocytes are …

[HTML][HTML] Ca2+ as the prime trigger of aerobic glycolysis in astrocytes

A Horvat, M Muhič, T Smolič, E Begić, R Zorec, M Kreft… - Cell Calcium, 2021 - Elsevier
Astroglial aerobic glycolysis, a process during which d-glucose is converted to l-lactate, a
brain fuel and signal, is regulated by the plasmalemmal receptors, including adrenergic …

Alterations in glucose metabolism on cognition: a possible link between diabetes and dementia

RE González-Reyes, G Aliev… - Current …, 2016 - ingentaconnect.com
The use of the carbohydrate glucose as an energetic source is essential for an adequate
function of the human body. The complex regulation of this molecule involves the …

Astrocytic energetics during excitatory neurotransmission: what are contributions of glutamate oxidation and glycolysis?

GA Dienel - Neurochemistry international, 2013 - Elsevier
Astrocytic energetics of excitatory neurotransmission is controversial due to discrepant
findings in different experimental systems in vitro and in vivo. The energy requirements of …

Nutritional ketosis as an intervention to relieve astrogliosis: Possible therapeutic applications in the treatment of neurodegenerative and neuroprogressive disorders

G Morris, M Maes, M Berk, AF Carvalho… - European …, 2020 - cambridge.org
Nutritional ketosis, induced via either the classical ketogenic diet or the use of emulsified
medium-chain triglycerides, is an established treatment for pharmaceutical resistant …

Requirement of Glycogenolysis for Uptake of Increased Extracellular K+ in Astrocytes: Potential Implications for K+ Homeostasis and Glycogen Usage in Brain

J Xu, D Song, Z Xue, L Gu, L Hertz, L Peng - Neurochemical research, 2013 - Springer
The importance of astrocytic K+ uptake for extracellular K+([K+] e) clearance during
neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It …