Matrix metalloproteinases, vascular remodeling, and vascular disease

X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

Pathophysiology and epidemiology of abdominal aortic aneurysms

IM Nordon, RJ Hinchliffe, IM Loftus… - Nature reviews …, 2011 - nature.com
Abdominal aortic aneurysms (AAAs) are found in up to 8% of men aged> 65 years, yet
usually remain asymptomatic until they rupture. Rupture of an AAA and its associated …

[图书][B] Rutherford's vascular surgery e-book

JL Cronenwett, KW Johnston - 2014 - books.google.com
Published in association with the Society for Vascular Surgery, Rutherford's Vascular
Surgery presents state-of-the-art updates on all aspects of vascular health care. Extensively …

[HTML][HTML] Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm

R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

Matrix metalloproteinase inhibitors as investigational and therapeutic tools in unrestrained tissue remodeling and pathological disorders

J Liu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …

Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease

MM Benjamin, RA Khalil - … Inhibitors: Specificity of Binding and Structure …, 2012 - Springer
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade various
components of the extracellular matrix (ECM). MMPs could also regulate the activity of …

[HTML][HTML] Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

MJ Bown, GT Jones, SC Harrison, BJ Wright… - The American Journal of …, 2011 - cell.com
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a
significant heritability. We carried out a genome-wide association discovery study of 1866 …

[HTML][HTML] Genetic and environmental contributions to abdominal aortic aneurysm development in a twin population

CM Wahlgren, E Larsson, PKE Magnusson… - Journal of vascular …, 2010 - Elsevier
BACKGROUND: The contribution of hereditary and environmental factors to the
development of abdominal aortic aneurysms (AAAs) is still partly unknown. The aim of this …

Association between 9p21 genomic markers and heart disease: a meta-analysis

GE Palomaki, S Melillo, LA Bradley - Jama, 2010 - jamanetwork.com
Context Associations between chromosome 9p21 single-nucleotide polymorphisms (SNPs)
and heart disease have been reported and replicated. If testing improves risk assessments …

[HTML][HTML] Abdominal aortic aneurysm and abdominal wall hernia as manifestations of a connective tissue disorder

GA Antoniou, GS Georgiadis, SA Antoniou… - Journal of vascular …, 2011 - Elsevier
BACKGROUND: Abdominal aortic aneurysms (AAAs) and abdominal wall hernias represent
chronic degenerative conditions. Both aortic aneurysms and inguinal hernias share common …