The 'how'and 'where'of plant micro RNA s

Y Yu, T Jia, X Chen - New Phytologist, 2017 - Wiley Online Library
Micro RNA s (mi RNA s) are small non‐coding RNA s, of typically 20–24 nt, that regulate
gene expression post‐transcriptionally through sequence complementarity. Since the …

[HTML][HTML] Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies

C Yao, S Dai, C Wang, K Fu, R Wu, X Zhao… - Biomedicine & …, 2023 - Elsevier
Luteolin is a flavonoid widely present in various traditional Chinese medicines. In recent
years, luteolin has received more attention due to its impressive liver protective effect, such …

Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

K Zhang, L Miorin, T Makio, I Dehghan, S Gao… - Science …, 2021 - science.org
The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2
outbreak worldwide has highlighted the need for understanding viral-host interactions …

mRNA recognition and packaging by the human transcription–export complex

B Pacheco-Fiallos, MK Vorländer, D Riabov-Bassat… - Nature, 2023 - nature.com
Newly made mRNAs are processed and packaged into mature ribonucleoprotein complexes
(mRNPs) and are recognized by the essential transcription–export complex (TREX) for …

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

SR Mihaylov, LM Castelli, YH Lin, A Gül, N Soni… - Nature …, 2023 - nature.com
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism
homeostasis, linking external stimuli to transcriptional co-activation of genes involved in …

A fungal effector suppresses the nuclear export of AGO1–miRNA complex to promote infection in plants

C Zhu, JH Liu, JH Zhao, T Liu… - Proceedings of the …, 2022 - National Acad Sciences
Communication between interacting organisms via bioactive molecules is widespread in
nature and plays key roles in diverse biological processes. Small RNAs (sRNAs) can travel …

The role of DEAD-box ATPases in gene expression and the regulation of RNA–protein condensates

K Weis, M Hondele - Annual review of biochemistry, 2022 - annualreviews.org
DEAD-box ATPases constitute a very large protein family present in all cells, often in great
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …

Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities

JD Lapek Jr, P Greninger, R Morris, A Amzallag… - Nature …, 2017 - nature.com
The formation of protein complexes and the co-regulation of the cellular concentrations of
proteins are essential mechanisms for cellular signaling and for maintaining homeostasis …

The m6A-methylase complex recruits TREX and regulates mRNA export

S Lesbirel, N Viphakone, M Parker, J Parker… - Scientific Reports, 2018 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant internal modification of
eukaryotic mRNA. This modification has previously been shown to alter the export kinetics …

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

GM Hautbergue, LM Castelli, L Ferraiuolo… - Nature …, 2017 - nature.com
Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Expression of …