The 'how'and 'where'of plant micro RNA s
Micro RNA s (mi RNA s) are small non‐coding RNA s, of typically 20–24 nt, that regulate
gene expression post‐transcriptionally through sequence complementarity. Since the …
gene expression post‐transcriptionally through sequence complementarity. Since the …
[HTML][HTML] Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
C Yao, S Dai, C Wang, K Fu, R Wu, X Zhao… - Biomedicine & …, 2023 - Elsevier
Luteolin is a flavonoid widely present in various traditional Chinese medicines. In recent
years, luteolin has received more attention due to its impressive liver protective effect, such …
years, luteolin has received more attention due to its impressive liver protective effect, such …
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression
The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2
outbreak worldwide has highlighted the need for understanding viral-host interactions …
outbreak worldwide has highlighted the need for understanding viral-host interactions …
mRNA recognition and packaging by the human transcription–export complex
B Pacheco-Fiallos, MK Vorländer, D Riabov-Bassat… - Nature, 2023 - nature.com
Newly made mRNAs are processed and packaged into mature ribonucleoprotein complexes
(mRNPs) and are recognized by the essential transcription–export complex (TREX) for …
(mRNPs) and are recognized by the essential transcription–export complex (TREX) for …
The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism
homeostasis, linking external stimuli to transcriptional co-activation of genes involved in …
homeostasis, linking external stimuli to transcriptional co-activation of genes involved in …
A fungal effector suppresses the nuclear export of AGO1–miRNA complex to promote infection in plants
C Zhu, JH Liu, JH Zhao, T Liu… - Proceedings of the …, 2022 - National Acad Sciences
Communication between interacting organisms via bioactive molecules is widespread in
nature and plays key roles in diverse biological processes. Small RNAs (sRNAs) can travel …
nature and plays key roles in diverse biological processes. Small RNAs (sRNAs) can travel …
The role of DEAD-box ATPases in gene expression and the regulation of RNA–protein condensates
DEAD-box ATPases constitute a very large protein family present in all cells, often in great
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …
Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities
The formation of protein complexes and the co-regulation of the cellular concentrations of
proteins are essential mechanisms for cellular signaling and for maintaining homeostasis …
proteins are essential mechanisms for cellular signaling and for maintaining homeostasis …
The m6A-methylase complex recruits TREX and regulates mRNA export
Abstract N 6-methyladenosine (m6A) is the most abundant internal modification of
eukaryotic mRNA. This modification has previously been shown to alter the export kinetics …
eukaryotic mRNA. This modification has previously been shown to alter the export kinetics …
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Expression of …
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Expression of …