Photodynamic therapy (PDT) is a well-established treatment option in the treatment of
certain cancerous and pre-cancerous lesions. Though best-known for its application in …

Background and Objectives Pathogen inactivation (PI)‐treated plasma and platelets are
increasingly becoming the products of choice, where licensed. This review summarizes the …

BACKGROUND The INTERCEPT Blood System pathogen reduction technology (PRT),
which uses amotosalen and ultraviolet A light treatment (amotosalen/UV‐PRT), inactivates …

Context.—Pathogen inactivation provides a proactive approach to cleansing the blood
supply. In the plasma fractionation and manufacturing industry, pathogen inactivation …

We performed a risk–benefit analysis for implementation of pathogen‐inactivated (PI)
apheresis platelets (APs) in the U nited S tates, focusing on the amotosalen/ultraviolet‐A …

Although existing clinical evidence shows that the transfusion of blood components is
becoming increasingly safe, the risk of transmission of known and unknown pathogens, new …

Background In the absence of curative treatment, such as stem cell transplant, regular
transfusions remain the mainstay of therapy for individuals with thalassemia major, a …

Remarkable improvements have been made in blood safety since the onset of the HIV
epidemic. However, the current paradigm does not prevent all transfusion-transmitted …

Transfusions of RBCs, platelets, and plasma are critical therapies for preterm neonates. A
majority of extremely low-birth-weight infants require at least 1 transfusion and many receive …

We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate
in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated …