There are many complex eye diseases which are the leading causes of blindness, however,
the pathogenesis of the complex eye diseases is not fully understood, especially the …

The development of effective antifungal agents remains a big challenge in view of the close
evolutionary relationship between mammalian cells and fungi. Moreover, rapid mutations of …

Chronic fungal infection of the cornea could lead to blindness if not treated properly. Topical
amphotericin B (AMP-B) is considered the first treatment of choice for ocular fungal infection …

Microbial keratitis (MK) is an infection of the cornea, caused by bacteria, fungi, parasites, or
viruses. MK leads to significant morbidity, being the fifth leading cause of blindness …

This study aims to develop efficient topical therapy for keratomycosis using
sertaconazolenitrate (STZN)-loaded leciplex (LP). The D-optimal design was used to …

Fungal keratitis is the primary cause of infectious corneal blindness in China. Currently,
early-stage treatment mainly involves the frequent administration of antifungal medications …

Polymicrobial infections are challenging to treat because we don't fully understand how
pathogens interact during infection and how these interactions affect drug efficacy. Candida …

Purpose To explore the therapeutic effect of chondroitin sulfate (CS) on Aspergillus
fumigatus (A. fumigatus) keratitis. Methods The nontoxic concentration of CS was …

Fungal keratitis is a serious corneal infection, which can lead to significant visual impairment
and blindness. The cGAS-STING signaling pathway has emerged as a key player in innate …

To improve the therapeutic effect of natamycin on fungal keratitis (FK), the grafted derivatives
of natamycin and gallic acid were obtained, and the effects of the grafted derivatives on …