Hypoxia is an environmental stressor that is instigated by low oxygen availability. It fuels the
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …

Cancer stem cells (CSCs) also known as tumour-initiating cells contribute not only to the
onset and progression of tumor in most cancer types, but also play a definitive role in …

Cancer-targeted therapy by a chemotherapeutic agent formulated in a nanoscale platform
has been challenged by complex and inefficient manufacturing, low drug loading, difficult …

Unreasonable disposal of sulfadoxine (SDX) causing food safety and eventually result water
pollution, and shows great significance of detection. A sensitive unit Aptamer (Apt) was …

Simple Summary The use of drugs based on nucleic acids is a promising direction in
antitumor therapy. Some modified oligonucleotide analogs, such as antisense …

Adipocyte-derived leptin activates multiple oncogenic signaling, leading to breast cancer
cell progression and metastasis. Hence, finding effective strategies to inhibit the oncogenic …

This study is a continuation of an investigation into the effect of a targeted component, a
peptide with an NGR, on the properties of the previously developed doxorubicin …

Despite the numerous scientific and technological advances made within the last decade
the attrition rates for new drug discovery remain as high as 95% for anticancer drugs. Recent …

Tumor angiogenesis is primarily regulated by vascular endothelial growth factor and its
receptor (VEGF-VEGFR) communication, which is involved in cancer cell growth …

Diindolylmethane (DIM), a bioactive compound rich in cruciferous vegetables, has been well
known for its health benefits, including anticancer properties. However, its clinical utilization …