The immune checkpoints are regulatory molecules that maintain immune homeostasis in
physiological conditions. By sending T cells a series of co-stimulatory or co-inhibitory signals …

Adoptive T cell therapy (ACT) is a fast developing, niche area of immunotherapy (IO), which
is revolutionising the therapeutic landscape of solid tumour oncology, especially metastatic …

Paclitaxel (Tx) is a widely used therapeutic chemical for breast cancer treatment; however,
cancer recurrence remains an obstacle for improved prognosis of cancer patients. In this …

Background: Monoclonal antibody (mAb) 6G5j is a novel anti-CEACAM monoclonal
antibody. Our aim was to investigate mAb 6G5j binding characteristics and to validate …

Multidrug-resistant Acinetobacter baumannii is regarded as a life-threatening pathogen
mainly associated with nosocomial and community-acquired pneumonia. Here, we show …

Simple Summary Cancers can grow and spread to different parts of the body. The aim of
immunotherapy is to stimulate the immune system to eliminate cancer cells in a selective …

Alternative splicing of messenger RNA (mRNA) precursors contributes to genetic diversity by
generating structurally and functionally distinct transcripts. In a disease state, alternative …

Increased concentrations of extracellular chromatin are observed in cancer, sepsis, and
inflammatory autoimmune diseases like systemic lupus erythematosus (SLE) or rheumatoid …

SOX10 is a key regulator of melanoma progression and promotes a melanocytic/
differentiated state. Here we identified melanoma cell lines lacking SOX10 expression which …

Background Prostatitis is an inflammatory disease of the prostate gland, which affects 2-16%
of men worldwide and thought to be a cause for prostate cancer (PCa) development …