Historically and anecdotally cannabinoids have been used as analgesic agents. In recent
years, there has been an escalating interest in developing cannabis-derived medications to …

Anxiety and related disorders are the most common mental conditions affecting the North
American population. Despite their established efficacy, first‐line antidepressant treatments …

The G-protein coupled receptors for Δ9-tetrahydrocannabinol, the major psychoactive
principle of marijuana, are known as cannabinoid receptors of type 1 (CB1) and 2 (CB2) and …

Pain is a complex phenomenon caused by noxious sensory stimuli or neuropathological
mechanisms. An individual's memories, expectations, and emotions modify the experience …

The enactment of California's Proposition 215 stipulates that patients may use marijuana for
medical reasons, provided that it is recommended by a physician. Yet, medical marijuana …

This systematic review aims to integrate the evidence on indications, efficacy, safety and
pharmacokinetics of medical cannabinoids in older subjects. The literature search was …

Objective Pooled analysis of nabiximols and placebo in randomized controlled studies
(RCTs) of chronic neuropathic pain. Design Systematic review and meta-analysis. Methods …

Chronic pain is a complex and challenging medical condition that affects millions of people
worldwide. Understanding the underlying mechanisms of chronic pain is a key goal of …

Introduction: Cannabidiol (CBD) is the second most abundant Phytocannabinoid in
Cannabis extracts. CBD has a binding affinity for several cannabinoid and cannabinoid …

Using 8-hour human laboratory experiments, we evaluated the analgesic efficacy of
vaporized cannabis in patients with neuropathic pain related to injury or disease of the …