Somatic or acquired mutations are postzygotic genetic variations that can occur within any
tissue. These mutations accumulate during aging and have classically been linked to …

Inborn errors of immunity (IEIs) are immunological disorders characterized by variable
susceptibility to infections, immune dysregulation and/or malignancies, as a consequence of …

Receptor clustering is the most critical step to activate extrinsic apoptosis by death receptors
belonging to the TNF superfamily. Although clinically unsuccessful, using agonist …

Primary immune regulatory disorders (PIRDs) are inborn errors of immunity caused by a loss
in the regulatory mechanism of the inflammatory or immune response, leading to impaired …

Dendritic cells (DCs) are crucial cells for initiating and maintaining immune response. They
play critical role in homeostasis, inflammation, and autoimmunity. A number of molecules …

Autoimmune lymphoproliferative syndrome (ALPS) is a primary disorder of lymphocyte
homeostasis, leading to chronic lymphoproliferation, autoimmune cytopenia, and increased …

Objective The complex pathogenesis of relapsed and refractory (R/R) immune
thrombocytopenia (ITP) contributes to the varied efficacy and tolerability of current treatment …

Monogenic autoimmune disorders represent an important tool to understand the
mechanisms behind central and peripheral immune tolerance. Multiple factors, both genetic …

Host control over infectious disease relies on the ability of cells in multicellular organisms to
detect and defend against pathogens to prevent disease. Evolution affords mammals with a …

Lymphoproliferation is defined by lymphadenopathy, splenomegaly, hepatomegaly, or
lymphocytic organ and tissue infiltration. The most common etiologies of lymphoproliferation …