To maintain protein homeostasis, AAA+ proteolytic machines degrade damaged and
unneeded proteins in bacteria, archaea and eukaryotes. This process involves the ATP …

Bacterial proteases are an extensive collection of enzymes that have vital roles in cell
viability, stress response and pathogenicity. Although their perturbation clearly offers the …

Regulated proteolysis is a vital process that affects all living things. Bacteria use energy-
dependent AAA+ proteases to power degradation of misfolded and native regulatory …

In prokaryotic cells and eukaryotic organelles, the ClpP protease plays an important role in
proteostasis. The disruption of the ClpP function has been shown to influence the infectivity …

The recent accelerated approval for use in extensively drug-resistant and multidrug-resistant-
tuberculosis (MDR-TB) of two first-in-class TB drugs, bedaquiline and delamanid, has …

The caseinolytic protease proteolytic subunit (ClpP) is a serine protease playing an
important role in proteostasis of eukaryotic organelles and prokaryotic cells. Alteration of …

The caseinolytic protease (ClpP) is part of a highly conserved proteolytic complex whose
disruption can lead to antibacterial activity but for which few specific inhibitors have been …

Caseinolytic protease P (ClpP) represents a central bacterial degradation machinery that is
involved in cell homeostasis and pathogenicity. The functional role of ClpP has been studied …

The cyclic acyldepsipeptide (ADEP) antibiotics are a new class of antibacterial agents that
kill bacteria via a mechanism that is distinct from all clinically used drugs. These molecules …

Caseinolytic peptidase P (ClpP), a double-ring peptidase with 14 subunits, collaborates with
ATPases associated with diverse activities (AAA+) partners to execute ATP-dependent …