It is well-recognized that, despite similar pain characteristics, some people with chronic pain
recover, whereas others do not. In this review, we discuss possible contributions and …

The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …

After nerve injury maladaptive changes can occur in injured sensory neurons and along the
entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain …

Chronic pain after breast cancer treatment is a major clinical problem, affecting 25 to 60% of
patients. Development of chronic pain after breast cancer treatment, as well as other surgical …

BACKGROUND: Many clinical trials have demonstrated the effectiveness of gabapentin and
pregabalin administration in the perioperative period as an adjunct to reduce acute …

Chronic pain is a global problem that has reached epidemic proportions. An estimated 20%
of adults suffer from pain, and another 10% are diagnosed with chronic pain each year …

Chronic pain is a classic example of gene× environment interaction: inflammatory and/or
nerve injuries are known or suspected to be the etiology of most chronic pain syndromes …

Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …

Abstract Background and Purpose In these guidelines, we aimed to develop evidence‐
based recommendations for the use of screening questionnaires and diagnostic tests in …

Background: Chronic postsurgical pain (CPSP) has been linked to many surgical settings.
The authors aimed to analyze functional genetic polymorphisms and clinical factors that …