The emergence of drug-resistant strains of Mycobacterium tuberculosis is a challenge to
global tuberculosis (TB) control. Although culture-based methods have been regarded as …

Pyrazinamide (PZA) is an important first-line drug in the treatment of tuberculosis (TB) and of
significant interest to the HIV-infected community due to the prevalence of TB-HIV …

ABSTRACT ARG-ANNOT (Antibiotic Resistance Gene-ANNOTation) is a new bioinformatic
tool that was created to detect existing and putative new antibiotic resistance (AR) genes in …

The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug
resistance in clinical samples, and improvements in global surveillance. Here we show how …

Antibiotic-resistant tuberculosis poses a global threat, causing the deaths of hundreds of
thousands of people annually. While whole-genome sequencing (WGS), with its …

Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …

The rapid diagnosis of rifampin resistance is hampered by a reported insufficient specificity
of molecular techniques for detection of rpoB mutations. Our objective for this study was to …

Whole-genome sequencing (WGS) is a newer alternative for tuberculosis (TB) diagnostics
and is capable of providing rapid drug resistance profiles while performing species …

The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR)
Mycobacterium tuberculosis complex (Mtbc) isolates challenges tuberculosis (TB) control …

Whole-genome sequencing (WGS) has the potential to accelerate drug-susceptibility testing
(DST) to design appropriate regimens for drug-resistant tuberculosis (TB). Several recently …