Electrolyte and acid-base disorders in chronic kidney disease and end-stage kidney failure

T Dhondup, Q Qian - Blood purification, 2017 - karger.com
The kidneys play a pivotal role in the regulation of electrolyte and acid-base balance. With
progressive loss of kidney function, derangements in electrolytes and acid-base inevitably …

The role of phosphate in kidney disease

MG Vervloet, S Sezer, ZA Massy, L Johansson… - Nature Reviews …, 2017 - nature.com
The importance of phosphate homeostasis in chronic kidney disease (CKD) has been
recognized for decades, but novel insights—which are frequently relevant to everyday …

[HTML][HTML] Strategies for phosphate control in patients with CKD

FC Barreto, DV Barreto, ZA Massy… - Kidney international reports, 2019 - Elsevier
Hyperphosphatemia is a common complication in patients with chronic kidney disease
(CKD), particularly in those requiring renal replacement therapy. The importance of …

Magnesium inhibits Wnt/β-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells

A Montes de Oca, F Guerrero, JM Martinez-Moreno… - PloS one, 2014 - journals.plos.org
Magnesium reduces vascular smooth muscle cell (VSMC) calcification in vitro but the
mechanism has not been revealed so far. This work used only slightly increased magnesium …

Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation

AD Ter Braake, PT Tinnemans, CM Shanahan… - Scientific reports, 2018 - nature.com
Magnesium has been shown to effectively prevent vascular calcification associated with
chronic kidney disease. Magnesium has been hypothesized to prevent the upregulation of …

Magnesium counteracts vascular calcification: passive interference or active modulation?

AD Ter Braake, CM Shanahan… - … , and vascular biology, 2017 - Am Heart Assoc
Over the last decade, an increasing number of studies report a close relationship between
serum magnesium concentration and cardiovascular disease risk in the general population …

[HTML][HTML] Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats

JM Diaz-Tocados, A Peralta-Ramirez… - Kidney international, 2017 - Elsevier
Although magnesium has been shown to prevent vascular calcification in vitro, controlled in
vivo studies in uremic animal models are limited. To determine whether dietary magnesium …

Serum magnesium and mortality in hemodialysis patients in the United States: a cohort study

E Lacson Jr, W Wang, L Ma… - American Journal of Kidney …, 2015 - Elsevier
Background Low serum magnesium levels in patients with kidney disease have been linked
to increased mortality. This study investigated whether similar associations existed in …

Cellular and molecular mechanisms of chronic kidney disease with diabetes mellitus and cardiovascular diseases as its comorbidities

PR Gajjala, M Sanati, J Jankowski - Frontiers in immunology, 2015 - frontiersin.org
Chronic kidney disease (CKD), diabetes mellitus (DM), and cardiovascular diseases (CVD)
are complex disorders of partly unknown genesis and mostly known progression factors …

Magnesium: a magic bullet for cardiovascular disease in chronic kidney disease?

NHJ Leenders, MG Vervloet - Nutrients, 2019 - mdpi.com
Magnesium is essential for many physiological functions in the human body. Its homeostasis
involves dietary intake, absorption, uptake and release from bone, swifts between the intra …